TITLE

Variant Creutzfeldt-Jakob disease: a summary of current scientific knowledge in relation to public health

AUTHOR(S)
Coulthart, Michael B.; Cashman, Neil R.
PUB. DATE
July 2001
SOURCE
CMAJ: Canadian Medical Association Journal;7/10/2001, Vol. 165 Issue 1, p51
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The prion diseases pose unique scientific, medical, veterinary and regulatory challenges. Here, we summarize current information bearing on the natural history, pathobiology and epidemiology of these disorders and public policy responses to the potential threats to public health posed, particularly, by bovine spongiform encephalopathy and variant Creutzfeldt Jakob disease (vCJD). Six years after the first case reports of vCJD, there is still no clear indication of the magnitude of the primary epidemic, or of the likelihood of lateral transmission of this untreatable disease by iatrogenic means, particularly by blood and blood products. However, the unsettling nature of the available evidence warrants prudence regarding public health policy and regulation, as well as a forward-looking approach to research.
ACCESSION #
4820012

 

Related Articles

  • Price transmission, BSE and structural breaks in the UK meat sector. Ana I. Sanjuán; P. J. Dawson // European Review of Agricultural Economics;6/01/2003, Vol. 30 Issue 2, p155 

    This paper examines transmission between producer and retail prices for beef, lamb and pork in the UK and the impact of public concern over bovine spongiform encephalopathy (BSE) in early 1996. We used the cointegration procedure of Johansen et al. 2000), which admits structural breaks in...

  • Possible new form of variant Creutzfeldt-Jakob disease detected in U.K. woman.  // Infectious Disease News;Feb2008, Vol. 21 Issue 2, p43 

    This article discusses findings of a study, which revealed a possible new form of variant Creutzfeldt-Jakob disease. The variant was suspected to be carried by a British woman who recently died. According to researchers, the variant Creutzfeldt-Jakob disease is a transmissible spongiform...

  • prion. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p628 

    A definition of the term "prion" is presented. It refers to a tiny, protein-based infectious particle, which transmits disease that cause degeneration of the central nervous system, including Creutzfeld-Jakob disease in humans and bovine spongiform encephalopathy (BSE) in cattle. Prisons are...

  • Variant Creutzfeldt-Jacob Disease: A Review of 150 Cases. Caronna, John J. // Neurology Alert;Jul2011, Vol. 29 Issue 11, p82 

    IN THE MID-1990S, VARIANT CREUTZFELDT-JAKOB DISEASE (vCJD) was recognized as an example of bovine-to-human spread of bovine spongiform encephalopathy (mad cow disease) by ingestion of meat products infected with the pathogenic prion protein. At present, more than 200 probable cases of vCJD have...

  • vCJD risk revised.  // New Scientist;5/27/2006, Vol. 190 Issue 2553, p7 

    This article focuses on the possibility of developing the human form of mad cow disease called variant Creutzfeldt-Jakob disease (vCJD). This is a big issue following the discovery of the agent responsible for vCJD in the appendixes of two people who have a different genetic make-up from all...

  • Creuzfeldt-Jakob disease.  // A-Z of Food Safety;2007, p79 

    A definition of the term "Creuzfeldt-Jakob disease" is presented. It refers to a disease that takes the form of a transmissible spongiform encephalopathy in humans and can be fatal within six months of contracting same. It has been described as the human equivalent to bovine spongiform...

  • Pulvinar Sign in Sporadic Creutzfeldt-Jakob Disease: Exploring the Diagnostic Modalities of Prion Diseases. Ravipati, Vijay; Mask-Bull, Lisa; Hale, Erin; Miller, Bernadette // Journal of Medical Cases;2013, Vol. 4 Issue 11, p765 

    Creutzfeldt-Jakob disease (CJD) refers to the most common transmissible spongiform encephalopathies. The distinction between a diagnosis of sporadically acquired CJD and the exogenously acquired CJD is important, and has previously been assisted by imaging modalities revealing the pulvinar sign....

  • Isolation from Cattle of a Prion Strain Distinct from That Causing Bovine Spongiform Encephalopathy. Béringue, Vincent; Bencsik, Anna; Le Dur, Annick; Reine, Fabienne; Thanh Lan Laï; Chenais, Nathalie; Tilly, Gaëlle; Biacabé, Anne-Gaëlle; Baron, Thierry; Vilotte, Jean-Luc; Laude, Hubert // PLoS Pathogens;Oct2006, Vol. 2 Issue 10, p0956 

    To date, bovine spongiform encephalopathy (BSE) and its human counterpart, variant Creutzfeldt-Jakob disease, have been associated with a single prion strain. This strain is characterised by a unique and remarkably stable biochemical profile of abnormal protease-resistant prion protein (PrPres)...

  • PrPSc accumulation in myocytes from sheep incubating natural scrapie. Andréoletti, O.; Simon, S.; Lacroux, C.; Morel, N.; Tabouret, G.; Chabert, A.; Lugan, S.; Corbière, F.; Ferré, P.; Foucras, G.; Laude, H.; Eychenne, F.; Grassi, J.; Schelcher, F. // Nature Medicine;Jun2004, Vol. 10 Issue 6, p591 

    Because variant Creutzfeldt-Jakob disease (vCJD) in humans probably results from consumption of products contaminated with tissue from animals with bovine spongiform encephalopathy, whether infectious prion protein is present in ruminant muscles is a crucial question. Here we show that...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics