Long term in vitro stability of fully integrated wireless neural interfaces based on Utah slant electrode array

Sharma, Asha; Rieth, Loren; Tathireddy, Prashant; Harrison, Reid; Solzbacher, Florian
February 2010
Applied Physics Letters;2/15/2010, Vol. 96 Issue 7, p073702
Academic Journal
We herein report in vitro functional stability and recording longevity of a fully integrated wireless neural inteace (INI). The INI uses biocompatible Parylene-C as an encapsulation layer, and was immersed in phosphate buffered saline (PBS) for a period of over 150 days. The full functionality (wireless radio-frequency power, command, and signal transmission) and the ability of INI to record artificial action potentials even after 150 days of PBS soaking without any change in signal/noise amplitude constitutes a major milestone in long term stability, and evaluate the encapsulation reliability, functional stability, and potential usefulness for future chronic implants.


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