TITLE

Occupational asthma and allergy in snow crab processing in Newfoundland and Labrador

AUTHOR(S)
Gautrin, D.; Cartier, A.; Howse, D.; Horth-Susin, L.; Jong, M.; Swanson, M.; Lehrer, S.; Fox, G.; Neis, B.
PUB. DATE
January 2010
SOURCE
Occupational & Environmental Medicine;Jan2010, Vol. 67 Issue 1, p4
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Risk factors and prevalence of occupational asthma (OA) and occupational allergy (OAl) in the snow crab-processing industry have been poorly studied. Objective: To estimate the prevalence of OA and OAl in snow crab-processing workers and determine their relationship with exposure to snow crab allergens and other potential risk factors. Methods: A total of 215 workers (120 female/95 male) were recruited from four plants in Newfoundland and Labrador, Canada in 2001-2002. Results from questionnaires, skin-prick tests to snow crab meat and cooking water, specific IgEs against the latter, spirometry and peak flow monitoring were used to develop a diagnostic algorithm. An index based on work history and exposure measurements of snow crab aeroallergens was developed to estimate the cumulative exposure for each worker. Results: The prevalences of almost certain or highly probable OA and OAl were 15.8% and 14.9%, respectively. A high cumulative exposure to crab allergens, in jobs mostly held by women, was associated with OA (odds ratio (OR)?=?14.0, 95% CI 3.0 to 65.8) (highest vs lowest Cumulative Exposure Index) and with OAl (OR?=?7.1, 95% CI 1.9 to 29.0); job held when symptoms started (cleaning, packing, freezing) also predicted OA (OR?=?3.9, 95% CI 1.6 to 8.7) and OAl (OR?=?3.2, 95% CI 1.4 to 7.5). Atopy (OR?=?2.8, 95% CI 1.2 to 6.8), female gender (OR?=?10.7, 95% CI 3.6 to 32.1) and smoking were significant determinants for OA (OR?=?3.1, 95% CI 1.3 to 7.4). Conclusions: The prevalences of OA and OAl are high in snow crab-processing workers of Canada's East Coast. Cumulative exposure to snow crab allergens was related to the prevalences of OA and OAl in a dose-response manner taking into account atopy, gender and smoking.
ACCESSION #
48182998

 

Related Articles

  • Snow crab allergy and asthma among Greenlandic workers -- a pilot study. Bønløkke, Jakob Hjort; Gautrin, Denyse; Sigsgaard, Torben; Lehrer, Samuel B.; Maghni, Karim; Cartier, André // International Journal of Circumpolar Health;2012, Vol. 71, p1 

    Objectives. To study snow crab sensitization, occupational allergy and asthma in the snow crab industry in Greenland, as high rates have been found in Canada, but no reports have emerged from the same industry in Greenland. Study design. Pilot survey. Methods. Twenty workers (19 of Inuit and 1...

  • Immunomodulation of the Allergic Inflammatory Response: New Developments. Araujo, Maria I.; Campos, Regis A.; Cardoso, Luciana S.; Oliveira, S�rgio C.; Carvalho, Edgar M. // Inflammation & Allergy - Drug Targets;Jun2010, Vol. 9 Issue 2, p73 

    Studies of the molecular mechanisms associated with allergic diseases have lead to a better understanding of the complex processes that underlie their pathogenesis. These mechanisms involve Th2- and Th1-type cells and also some recently described cytokines, such as IL-25 and IL-33. Regulatory...

  • Healthy human T-cell responses to Aspergillus fumigatus antigens. Kanafani, Zeina A.; Klepser, Michael E. // Journal of Invasive Fungal Infections;2010, Vol. 4 Issue 2, p69 

    Aspergillus allergens are described as proteins that are recognized in patients with hypersensitivity syndromes such as allergic bronchopulmonary aspergillosis and Aspergillus-induced asthma. However, findings from this study indicate that (at least) some of these protein are not only allergens,...

  • Lung function, asthma paradox, atopy, and risk factors in Mexican spirometry-diagnosed asthmatic patients. Recio-Vega, Rogelio; Gabriel, Antonio Padua; Sánchez-Cabral, Olivia; Ocampo-Gómez, Guadalupe Leticia; Rincón-Castañeda, Cuauthémoc // Allergy & Asthma Proceedings;May/Jun2007, Vol. 28 Issue 3, p353 

    Despite long-term studies, still not much is known about the asthma triggering factors and its sometimes controversial results. Probably one of the major problems of controversy is the lack of specific and accurate diagnosis of this disease. The aim of this study was to assess lung function,...

  • Defining allergy. Morris, Adrian // Practice Nurse;5/8/2009, Vol. 37 Issue 9, p18 

    The article explains allergy terminology and provides an overview of immune reactions seen in allergic diseases such as asthma, hayfever, and eczema. The distinctions among allergy, intolerance, and hypersensitivity are discussed. The definitions for atopy, allergens, and anaphylaxis are...

  • The Relationship between Maternal Atopy and Childhood Asthma in Pretoria, South Africa. Abbott, Salome; Becker, Piet; Green, Robin J. // ISRN Allergy;2013, p1 

    Introduction. Asthma is the commonest chronic condition of children. Diagnosis of this condition remains difficult. Many surrogate markers are used, such as documenting evidence of atopy. Method. A random sample of asthmatic children and their mothers attending the Children's Chest and Allergy...

  • N-Acetyltransferases as Markers for Asthma and Allergic/Atopic Disorders. Batra, Jyotsna; Ghosh, Balaram // Current Drug Metabolism;Jul2008, Vol. 9 Issue 6, p546 

    An increasing prevalence of asthma noted worldwide has stimulated research on the phenotypic complexity resulting from interaction between the genetic and environmental components. Particularly, an increase in the prevalence of allergic rhinitis and asthma in industrialized countries indicate...

  • Simultaneous determination of two major snow crab aeroallergens in processing plants by use of isotopic dilution tandem mass spectrometry. Abdel Rahman, Anas; Gagné, Sébastien; Helleur, Robert // Analytical & Bioanalytical Chemistry;Aug2012, Vol. 404 Issue 2, p821 

    Snow crab is a major fishery in the North Atlantic region. During crab processing the proteins are aerosolized and some are responsible for development of occupational asthma. Tropomyosin and arginine kinase have recently been reported as major snow crab allergens. A liquid chromatographic...

  • Monoclonal Antibodies in Allergy; Current Applications and Promising Trials. Ozdemir, Cevdet // Recent Patents on Inflammation & Allergy Drug Discovery;Nov2009, Vol. 3 Issue 3, p201 

    Allergic disorders, including asthma, allergic rhinoconjunctivitis, atopic dermatitis, food allergies, urticaria and anaphylaxis have significant impacts on our daily lives. Innovation of novel treatment modalities targeting effector cells, cytokines, receptors or signaling pathways may bring...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics