Review: First-line low-dose thiazides and ACE inhibitors reduce mortality and morbidity in adults with hypertension

Shah, Nirav R.; Ogedegbe, Gbenga
January 2010
ACP Journal Club;1/19/2010, Vol. 152 Issue 1, p3
Academic Journal
The article discusses a study conducted by researcher J.M. Wright and colleagues to know benefits of major first-line antihypertensive drug classes. The study has found that in adults with hypertension, low-dose thiazides have the most evidence for cardiovascular benefit followed by angiotensin-converting enzyme inhibitors. Thiazides accounted for 25% of antihypertensive prescriptions in Great Britain and 16% in the U.S. in 2000.


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