Solution structure of the Equine Infectious Anemia Virus p9 protein: a rationalization of its different ALIX binding requirements compared to the analogous HIV-p6 protein
- Structural Model of the Rev Regulatory Protein from Equine Infectious Anemia Virus. Yungok Ihm; Sparks, Wendy O.; Jae-Hyung Lee; Cao, Haibo; Carpenter, Susan; Cai-Zhuang Wang; Kai-Ming Ho; Dobbs, Drena // PLoS ONE;2009, Vol. 4 Issue 1, p1
Rev is an essential regulatory protein in the equine infectious anemia virus (EIAV) and other lentiviruses, including HIV-1. It binds incompletely spliced viral mRNAs and shuttles them from the nucleus to the cytoplasm, a critical prerequisite for the production of viral structural proteins and...
- Structure-based in silico identification of ubiquitin-binding domains provides insights into the ALIX-V:ubiquitin complex and retrovirus budding. Keren-Kaplan, Tal; Attali, Ilan; Estrin, Michael; Kuo, Lillian S; Farkash, Efrat; Jerabek-Willemsen, Moran; Blutraich, Noa; Artzi, Shay; Peri, Aviyah; Freed, Eric O; Wolfson, Haim J; Prag, Gali // EMBO Journal;2/13/2013, Vol. 32 Issue 4, p538
The ubiquitylation signal promotes trafficking of endogenous and retroviral transmembrane proteins. The signal is decoded by a large set of ubiquitin (Ub) receptors that tether Ub-binding domains (UBDs) to the trafficking machinery. We developed a structure-based procedure to scan the protein...
- ESCRT requirements for EIAV budding. Sandrin, Virginie; Sundquist, Wesley I. // Retrovirology;2013, Vol. 10 Issue 1, p1
Background Retroviruses and many other enveloped viruses usurp the cellular ESCRT pathway to bud from cells. However, the stepwise process of ESCRT-mediated virus budding can be challenging to analyze in retroviruses like HIV-1 that recruit multiple different ESCRT factors to initiate budding....
- Computational modeling suggests dimerization of equine infectious anemia virus rev is required for RNA binding. Umunnakwe, Chijioke N.; Loyd, Hyelee; Cornick, Kinsey; Chavez, Jerald R.; Dobbs, Drena; Carpenter, Susan // Retrovirology;2014, Vol. 11 Issue 1, preceding p1
Background The lentiviral Rev protein mediates nuclear export of intron-containing viral RNAs that encode structural proteins or serve as the viral genome. Following translation, HIV-1 Rev localizes to the nucleus and binds its cognate sequence, termed the Rev-responsive element (RRE), in...
- Equine infectious anaemia in Ireland: characterisation of the virus. Mooney, Jean; Flynn, Orla; Sammin, Dónal // Veterinary Record: Journal of the British Veterinary Association;10/21/2006, Vol. 159 Issue 17, p570
A letter to the editor is presented about the diagnosis of infection with Equine infectious anemia virus in Irish horses.
- Supplementary Material. // Viruses (1999-4915);2014, Vol. 6 Issue 11, pS1
A diagram is presented which explains the evolution of S2 gene of virus equine infectious anemia.
- Structure of the Bro1 Domain Protein BROX and Functional Analyses of the ALIX Bro1 Domain in HIV-1 Budding. Zhai, Qianting; Landesman, Michael B.; Robinson, Howard; Sundquist, Wesley I.; Hill, Christopher P. // PLoS ONE;2011, Vol. 6 Issue 12, p1
Background: Bro1 domains are elongated, banana-shaped domains that were first identified in the yeast ESCRT pathway protein, Bro1p. Humans express three Bro1 domain-containing proteins: ALIX, BROX, and HD-PTP, which function in association with the ESCRT pathway to help mediate intraluminal...
- Structural insights into the Cyclin T1—Tat—TAR RNA transcription activation complex from EIAV. Anand, Kanchan; Schulte, Antje; Vogel-Bachmayr, Karin; Scheffzek, Klaus; Geyer, Matthias // Nature Structural & Molecular Biology;Dec2008, Vol. 15 Issue 12, p1287
The replication of many retroviruses is mediated by a transcriptional activator protein, Tat, which activates RNA polymerase II at the level of transcription elongation. Tat interacts with Cyclin T1 of the positive transcription-elongation factor P-TEFb to recruit the transactivation-response...
- FOCUS ON EIA. Pascoe, Elaine // Practical Horseman;Oct2008, Vol. 36 Issue 10, p83
The article provides information on equine infectious anemia (EIA).
- 752. Equine Infectious Anemia Virus Pseudotyped with the Vesicular Stomatitis Virus G-Protein, Preferentially Targets Neural Precursors in the Adult Mouse Brain. Ghashghaei, Troy; Patel, Manij; Olsen, John; Anton, Eva // Molecular Therapy;Jun2005, Vol. 11, p292
An abstract of the article "Equine Infectious Anemia Virus Pseudotyped with the Vesicular Stomatitis Virus G-Protein, Preferentially Targets Neural Precursors in the Adult Mouse Brain," by Troy Ghashghaei, Manij Patel, John Olsen and Eva Anton is presented.