TITLE

Detection of Multiple Mutations in a Single Cell

PUB. DATE
February 2010
SOURCE
Fertility Weekly;2/8/2010, p8
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study which determines the effect of preimplantation genetic diagnosis (PGD) in detecting three different mutations in one cell by T.M. Alberola and colleagues in Spain. It outlines how the researchers used PGD and has determined the successful procedure of detecting three different mutations in a single cell. The researchers note that the combination of PGD allows the simultaneous diagnosis of two diseases caused by different mutations in a single embryonic cell.
ACCESSION #
48080004

 

Related Articles

  • Preimplantation genetic diagnosis: technological advances to improve accuracy and range of applications. Kuliev, Anver; Verlinsky, Yury // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Apr2008, Vol. 16 Issue 4, p532 

    Preimplantation genetic diagnosis (PGD) is an option for couples who are at risk that enables them to have unaffected progeny without facing the risk of pregnancy termination after prenatal diagnosis as currently practiced. It is also one of the practical tools used in assisted reproduction...

  • Study shows taking cell of embryo during IVF is safe. Ford, Omar // Medical Device Daily;7/6/2012, Vol. 16 Issue 130, Special section p1 

    The article discusses the study conducted by researchers at the University Clinic in Brussels, Belgium which performs approximately 600 Preimplantation genetic diagnosis (PGD) cycles annually, that claimed the process is highly safe. PGD is the taking of a cell from a developing embryo during In...

  • PGD and PND: Which and why for who? Cordier, A. G.; Benachi, A.; Frydman, R. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;May2010 S1 Supplement, Vol. 20, pS12 

    In the past few years we have been the witness of huge steps forwards in reproductive technologies and in antenatal researchs. Specifically genetic diagnosis has created a range of possibilities. The technical improvement allows knowing the prognostic possibilities in a situation of limited...

  • PGD activity in France: the French specificities. Di Costanzo, S.; Lévy, P.; Thépot, F.; Shojaei, T. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;May2010 S1 Supplement, Vol. 20, pS40 

    Context: In France, preimplantation genetic diagnosis (PGD) has been regulated by the 2004 bioethics law. According to this law, a PGD is done only for couples with a high risk of transmitting a serious and incurable inherited disease. Each PGD indication has to be authorized by the local...

  • Attitudes of German infertile couples towards preimplantation genetic diagnosis for different uses: a comparison to international studies. Borkenhagen, A.; Brähler, E.; Wisch, S.; Stöbel-Richter, Y.; Strauss, B.; Kentenich, H. // Human Reproduction;Jul2007, Vol. 22 Issue 7, p2051 

    : BACKGROUND In Germany, preimplantation genetic diagnosis (PGD) is currently not legal, but there is still a controversial debate about legalization. Studies about the attitudes of infertile couples towards PGD are rare. : METHODS A survey was conducted with 265 German infertile couples about...

  • Comprehensive microarray genetic analyses on single cell(s) from polar bodies or embryos to determine 23-chromosome aneuploidy, structural chromosome aberrations and genome-wide scans using single nucleotide polymorphisms (SNPs); to identify what partner provided the extra chromosome in aneuploid embryos; and to determine what embryo implanted following an in vitro fertilization (IVF) cycle. Kearns, W. G.; Pen, R.; Benner, A.; Siegel, A.; Widra, E.; Leach, R. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;May2010 S1 Supplement, Vol. 20, pS9 

    Objective: To amplify DNA from a polar body, a single embryonic blastomere or trophectoderm cell(s) and to perform complex genetic analyses. Design: Prospective study. Materials and Methods: A modified whole genome amplification (WGA) protocol was performed on 513 single cells (112 WBCs, 367...

  • PGD for β-thalassaemia: the first case in Turkey. Kahraman, S.; BenKhalifa, M.; Dönmez, E.; Biricik, A; Fiorentino, F. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;2002 Supplement 2, Vol. 4 Issue S2, p41 

    Objective: Here we present the first preimplantation genetic diagnosis for the single germ disorder β-thalassaemia in Turkey. Materials/Methods: A Cypriot couple who had one child affected by β-thalassaemia was referred to our centre. β-globin germ mutations were detected on both...

  • Session 59: Preimplantation genetic diagnosis.  // Human Reproduction;Jul2007 Supplement 1, Vol. 22, pi91 

    The article presents abstracts on preimplantation genetic diagnosis, including using linked markers in preimplantation genetic diagnosis for Huntington's disease, preimplantation genetic haplotyping (PGH) in testing embryos for monogenic disease and cytogenetic analysis of embryos from couples...

  • Preimplantation diagnosis of monogenic diseases in GENNET. Putzova, M.; Eliasova, I.; Pecnova, L.; Krutilkova, V.; Brandejska, M.; Stejskal, D. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;May2010 S1 Supplement, Vol. 20, pS34 

    Aim: In 2007 we completed the first in vitro fertilization cycle (IVF) followed by preimplantation genetic diagnostics (PGD) of cystic fibrosis. Since than, we have performed over 65 cycles with scheduled PGD for 27 different monogenic diseases all types of indication: X-linked, autosomal...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics