Enhanced photothermal therapy assisted with gold nanorods using a radially polarized beam

Hong Kang; Baohua Jia; Jingliang Li; Morrish, Dru; Min Gu
February 2010
Applied Physics Letters;2/8/2010, Vol. 96 Issue 6, p063702
Academic Journal
We report on the use of a radially polarized beam for photothermal therapy of cancer cells labeled with gold nanorods. Due to a three-dimensionally distributed electromagnetic field in the focal volume, the radially polarized beam is proven to be a highly efficient laser mode to excite gold nanorods randomly oriented in cancer cells. As a result, the energy fluence for effective cancer cell damage is reduced to one fifth of that required for a linearly polarized beam, which is only 9.3% of the medical safety level.


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