Bias correction of estimates of familial risk from population-based cohort studies

Leu, Monica; Czene, Kamila; Reilly, Marie
February 2010
International Journal of Epidemiology;Feb2010, Vol. 39 Issue 1, p80
Academic Journal
Background In addition to guiding molecular epidemiology investigations, estimates of the increased risk of disease in relatives of affected persons are also important for screening and counselling decisions. Since precise estimation of such familial risks (FRs) requires large sample sizes, many of the estimates in common use have been obtained from historical electronic records of disease in entire populations, where the relatives of affected and unaffected persons are compared. These estimates may be biased due to failure to identify relatives as affected if they are diagnosed before the start-up date of disease registration.


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