TITLE

Individual white matter fractional anisotropy analysis on patients with MRI negative partial epilepsy

AUTHOR(S)
Duning, Thomas; Kellinghaus, Christoph; Mohammadi, Siawoosh; Schiffbauer, Hagen; Keller, Simon; Ringelstein, E. Bernd; Knecht, Stefan; Deppe, Michael
PUB. DATE
February 2010
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Feb2010, Vol. 81 Issue 2, p136
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background Conventional structural MRI fails to identify a cerebral lesion in 25% of patients with cryptogenic partial epilepsy (CPE). Diffusion tensor imaging is an MRI technique sensitive to microstructural abnormalities of cerebral white matter (WM) by quantification of fractional anisotropy (FA). The objectives of the present study were to identify focal FA abnormalities in patients with CPE who were deemed MRI negative during routine presurgical evaluation. Methods Diffusion tensor imaging at 3T was performed in 12 patients with CPE and normal conventional MRI and in 67 age matched healthy volunteers. WM integrity was compared between groups on the basis of automated voxel-wise statistics of FA maps using an analysis of covariance. Volumetric measurements from high resolution T1-weighted images were also performed. Results Significant FA reductions in WM regions encompassing diffuse areas of the brain were observed when all patients as a group were compared with controls. On an individual basis, voxel based analyses revealed widespread symmetrical FA reduction in CPE patients. Furthermore, asymmetrical temporal lobe FA reduction was consistently ipsilateral to the electroclinical focus. No significant correlations were found between FA alterations and clinical data. There were no differences in brain volumes of CPE patients compared with controls. Conclusion Despite normal conventional MRI, WM integrity abnormalities in CPE patients extend far beyond the epileptogenic zone. Given that unilateral temporal lobe FA abnormalities were consistently observed ipsilateral to the seizure focus, analysis of temporal FA may provide an informative in vivo investigation into the localisation of the epileptogenic zone in MRI negative patients.
ACCESSION #
48013121

 

Related Articles

  • The optimal use of contrast agents at high field MRI. Trattnig, Siegfried; Pinker, Kathia; Ba-Ssalamah, Ahmed; Nöbauer-Huhmann, Iris-Melanie; Nöbauer-Huhmann, Iris-Melanie // European Radiology;Jun2006, Vol. 16 Issue 6, p1280 

    The intravenous administration of a standard dose of conventional gadolinium-based contrast agents produces higher contrast between the tumor and normal brain at 3.0 Tesla (T) than at 1.5 T, which allows reducing the dose to half of the standard one to produce similar contrast at 3.0 T compared...

  • MRI.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1500 

    An encyclopedia entry for the medical acronym "MRI," which refers to magnetic resonance imaging, is presented.

  • New UK stroke strategy adds £105M for training, awareness.  // Medical Device Daily;12/7/2007, Vol. 11 Issue 222, p1 

    The article reports on a plan to revolutionize stroke services in Great Britain announced by Health Secretary Alan Johnson. Under the plan, anyone in a higher-risk group who suffers a minor stroke will receive a magnetic resonance imaging (MRI) scan within 24 hours. The aim of the program is to...

  • How does MRI work?  // Patient Care;Jun2002, Vol. 36 Issue 8, p24 

    Explains how magnetic resonance imaging (MRI) works. Difference between computed tomography scans and MRI; Discussion of how an MR image is created; Strength of the magnets used for MRI.

  • Three-dimensional muscular architecture of the human tongue determined in vivo with diffusion tensor magnetic resonance imaging. Gilbert, Richard J.; Napadow, Vitaly J. // Dysphagia (0179051X);Winter2005, Vol. 20 Issue 1, p1 

    The myoarchitecture of the tongue is believed to consist of a complex network of interwoven fibers, which function together to produce a near limitless array of functional deformations. These deformations contribute mechanically to speech production and to oral cavity food handling during...

  • Terminology for our times. Grove, Matthew L. // BMJ: British Medical Journal (International Edition);7/19/2003, Vol. 327 Issue 7407, p166 

    Presents a letter to the editor concerning imaging investigations. Comments on the research by Hayward; Problems with less experienced investigators;; Misuse of magnetic resonance imaging.

  • Trauma musculoskeletal ultrasound. Kshitij Mankad; Edward Hoey; Andrew Grainger; Dominic Barron // Emergency Radiology;Mar2008, Vol. 15 Issue 2, p83 

    Abstract  Musculoskeletal ultrasound has benefited from the recent exponential improvement in probe technology to the extent that it is now the imaging modality of choice for many peripheral soft tissue injuries. This article aims to highlight these areas and encourage the use of...

  • Applications of quantitative T1, T2, and proton density to diagnosis. Chang, Kevin J.; Jara, Hernán // Applied Radiology;Jan2005 Supplement, Vol. 34, p34 

    Quantitative magnetic resonance imaging (Q-MRI) differs sharply from conventional directly acquired MRi in that objective measures (such as the trio of basic MR properties: T1, T2, and proton density(PD)) are used for analysis as well as further postprocessing rather than relative signal...

  • Opitz trigonocephaly syndrome presenting with sudden unexplained death in the operating room: a case report.  // Journal of Medical Case Reports;2011, Vol. 5 Issue 1, p1 

    The article presents the case of a Caucasian baby who died at five months of age during surgical correction of opitz trigonocephaly C syndrome (OTCS). OTCS is a heterogeneous genetic disorder which occurs sporadically. At 40 weeks post-conceptional age brain magnetic resonance imaging (MRI)...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics