The impact of experimental hypoperfusion on subsequent kidney function

Saotome, Takao; Ishikawa, Ken; May, Clive N.; Birchall, Ian E.; Bellomo, Rinaldo
March 2010
Intensive Care Medicine;Mar2010, Vol. 36 Issue 3, p533
Academic Journal
To investigate the short- and medium-term renal hemodynamic and functional responses to both short and sustained hypoperfusion. Eleven Merinos ewes. Animal laboratory of the University Physiology Institute. Prospective observational study. Studies were performed in conscious sheep after unilateral nephrectomy with a vascular occluder and flow probe implanted on the remaining renal artery. In five sheep, renal blood flow (RBF) was reduced by 25, 50 and 75%, respectively, by acute vascular occlusion for 30 min at weekly intervals. In another six sheep, RBF was reduced by 80% for 2 h. After 25, 50 or 75% renal hypoperfusion for 30 min, there was no associated extended loss of renal function. During 2 h of 80% hypoperfusion, urine output decreased from 80 to 17 ml, and creatinine clearance from 32 to 3 ml/min, whereas plasma creatinine increased from 103 to 132 μmol/l, and fractional excretion of sodium and urea increased. Release of occlusion induced brief hyperemia before all measured variables returned to normal within 8 h and remained normal for the following 72 h. At autopsy, the kidneys were histopathologically normal. Various degrees of renal hypoperfusion for 30 min did not induce prolonged changes in renal function or blood flow. Even with sustained severe hypoperfusion, there was rapid recovery to baseline function and flow. Unlike total ischemia, severe hypoperfusion alone is insufficient to induce subsequent persistent AKI.


Related Articles

  • Feasibility of Renal Artery Stenting Before, During, and After Endovascular Aneurysm Repair With Suprarenal Fixation Endograft. Melissano, Germano; Civilini, Efrem; Baccellieri, Domenico; Montorfano, Matteo; Chiesa, Roberto // Vascular & Endovascular Surgery;Apr/May2007, Vol. 41 Issue 2, p140 

    Suprarenal fixation by means of proximal bare stent may help prevent endograft migration and proximal endoleak. It seems not to compromise renal perfusion and function; however, it is still unclear whether its presence is in conflict with stenting of the renal arteries to treat associated renal...

  • Relation between blood- and urine-amphetamine concentrations in impaired drivers as influenced by urinary pH and creatinine. Jones, A. W.; Karlsson, L // Human & Experimental Toxicology;Dec2005, Vol. 24 Issue 12, p615 

    Amphetamine undergoes extensive renal excretion and significant amounts are present in urine as the unchanged parent drug. This prompted us to investigate whether a quantitative relationship existed between blood and urine concentrations of amphetamine in the body fluids of drug-impaired drivers...

  • Hypertension--Pathophysiology of Renal Artery Stenosis: Clinical Experimental Investigations. Kivelitz, Hans; Meyer, Wolfgang; Koehler, Joseph; Kremer, Karl // Angiology;Jun1978, Vol. 29 Issue 6, p442 

    This article reports that the aim of the correction of renal arterial stenosis is the reduction in the body arterial blood pressure. However, only in few cases is the goal reached. Therefore the effect of renal artery stenosis on the hemodynamics of the affected kidney calls for a general...

  • High glucose augments angiotensin II action by inhibiting NO synthesis in in vitro microperfused rabbit afferent arterioles. Arima, Shuji; Ito, Sadayoshi; Omata, Ken; Takeuchi, Kazuhisa; Abe, Keishi // Kidney International;Sep1995, Vol. 48 Issue 3, p683 

    High glucose augments angiotensin II action by inhibiting NO synthesis in in vitro microperfused rabbit afferent arterioles. Preglomerular afferent arteriole (Af-Art) is a crucial vascular segment in the control of glomerular hemodynamics. We have recently reported that vascular reactivity of...

  • Naloxone inhibits renal hemodynamic effect of head-out water immersion in humans. van Tilborg, Karin A.; Rabelink, Ton J.; Koomans, Hein A. // Kidney International;Sep1995, Vol. 48 Issue 3, p860 

    Naloxone inhibits renal hemodynamic effect of head-out water immersion in humans. Head-out water immersion (HOI) is followed by renal vasodilation and natriuresis, in association with a fall in blood pressure. The latter suggests an exaggerated sympathetic suppression. We studied the role of...

  • EFFECT OF SEROTONIN ON THE RENAL ARTERIES OF THE GUINEA PIG AND THE RABBIT. Virtama, P.; Jänkälä, E. // Angiology;Aug1961, Vol. 12 Issue 8, p372 

    The effect of serotonin on the renal arteries down to the radiating cortical arterioles was examined by injecting this agent through a polyethylene catheter into the aorta just above the origins of the renal arteries. Radiographic contrast mass (Dionoasil aqueous) was injected immediately after...

  • Studies of renal autoregulation in pancreatectomized and streptozotocin diabetic rats. Mauer, S. Michael; Brown, David M.; Steffes, Michael W.; Azar, Sylvia // Kidney International;Mar1990, Vol. 37 Issue 3, p909 

    We studied renal autoregulation in pancreatectomized Munich-Wistar diabetic rats and in their sham-operated controls. In a second experiment we studied renal autoregulation in untreated and insulin treated streptozotocin diabetic Munich-Wistar rats and their nondiabetic controls. In the first...

  • ARTERIAL, CAPILLARY, AND VENOUS PHASE ARTERIOGRAPHY IN THE EVALUATION OF RENAL ISCHEMIA. Derrick, John R.; Cooley, Robert N.; Spencer, Don C.; Brown, R. W. // Angiology;Feb1963, Vol. 14 Issue 2, p84 

    Studies the arterial, capillary, and venous phases of renal vascular flow in dogs. Occurrence of changes in the vasculature after three to four weeks after surgery; Constriction of the main renal artery in three animals with silk ligature; Angiographical images of the kidneys after surgery.

  • Giant Renal Artery Aneurysms. Cikrit, Dolores F.; Szwed, James J.; Burkhart, Harold M.; Dalsing, Michael C. // Vascular Surgery;Nov/Dec2000, Vol. 34 Issue 6, p513 

    Reports on the surgical treatment of giant renal artery aneurysms (RAA) with partial excision and ligation. Approach on small renal artery aneurysms; Diagnosis of a patient with urethral obstruction by giant RAA; Location of the aneurysms in the patients; Rationale for the use of surgery;...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics