Tamiflu still prudent for pandemic influenza, PHAC maintains
- Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition. Vavricka, Christopher J.; Qing Li; Wu, Yan; Qi, Jianxun; Wang, Mingyang; Liu, Yue; Gao, Feng; Liu, Jun; Feng, Enguang; He, Jianhua; Wang, Jinfang; Liu, Hong; Jiang, Hualiang; Gao, George F. // PLoS Pathogens;Oct2011, Vol. 7 Issue 10, Special section p1
The 2009 H1N1 influenza pandemic (pH1N1) led to record sales of neuraminidase (NA) inhibitors, which has contributed significantly to the recent increase in oseltamivir-resistant viruses. Therefore, development and careful evaluation of novel NA inhibitors is of great interest. Recently, a...
- Antidote. // Medical Marketing & Media;Jun2009, Vol. 44 Issue 6, p9
The article presents the author's insights on H1N1, also known as swine flu, and the anti-viral drugs Tamiflu and Relenza as an antidote to it. She provides information on the influenza as a genetic material in an envelope composed of hemagglutinin (H) and neuraminidase (N) which allow the...
- Influenza. Brody, Herb // Nature;12/8/2011 Supplement, Vol. 480 Issue 7376, pS1
An introduction is presented in which the editor discusses various reports within the issue on topics including the efficacy of Influenza vaccines, the neuraminidase inhibitors oseltamivir (Tamiflu) and zanamivir (Relenza), and the flu pandemic in 2009.
- Correction. // Emerging Infectious Diseases;Nov2011, Vol. 17 Issue 11, p2180
A correction to the article "Reassortment of Ancient Neuraminidase and Recent Hemagglutinin in Pandemic (H1N1) 2009 Virus" that was published in a previous issue is presented.
- Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus, Mexico. Ramirez-Gonzalez, José Ernesto; Gonzalez-Duran, Elizabeth; Alcantara-Perez, Patricia; Wong-Arambula, Claudia; Olivera-Diaz, Hiram; Cortez-Ortiz, Iliana; Barrera-Badillo, Gisela; Nguyen, Ha; Gubareva, Larisa; Lopez-Martinez, Irma; Díaz-Quiñonez, Jose Alberto; Lezana-Fernández, Miguel Angel; Gatell-Ramírez, Hugo Lopez; Villalobos, Jose Angel Cordova; Hernández-Avila, Mauricio; Alpuche-Aranda, Celia // Emerging Infectious Diseases;Feb2011, Vol. 17 Issue 2, p283
During May 2009-April 2010, we analyzed 692 samples of pandemic (H1 N1 ) 2009 virus from patients in Mexico. We detected the H275Y substitution of the neuraminidase gene in a specimen from an infant with pandemic (HIN1) 2009 who was treated with oseltamivir. This virus was susceptible to...
- Changes in Texas Poison Center Call Patterns in Response to H1N1 Influenza Outbreak. Forrester, Mathias B. // Texas Public Health Journal;Fall2012, Vol. 64 Issue 4, p14
The article looks into the changes in the pattern of exposure reports to poison centers in Texas in relation to the H1N1 influenza outbreak. The authors mention that during the outbreak, the number of neuraminidase inhibitor and hand sanitizer exposures increased significantly. They state that...
- What happened after the initial global spread of pandemic human influenza virus A (H1N1)? A population genetics approach. Martinez-Hernandez, Fernando; Jimenez-Gonzalez, Diego Emiliano; Martinez-Flores, Arony; Villalobos-Castillejos, Guiehdani; Vaughan, Gilberto; Kawa-Karasik, Simon; Flisser, Ana; Maravilla, Pablo; Romero-Valdovinos, Mirza // Virology Journal;2010, Vol. 7, p196
Viral population evolution dynamics of influenza A is crucial for surveillance and control. In this paper we analyzed viral genetic features during the recent pandemic caused by the new influenza human virus A H1N1, using a conventional population genetics approach based on 4689 hemagglutinin...
- Novel Pandemic Influenza A(H1N1) Viruses Are Potently Inhibited by DAS181, a Sialidase Fusion Protein. // PLoS ONE;2009, Vol. 4 Issue 11, p1
The article discusses a study which examined the activity of DAS181 against several pandemic influenza A (H1N1) virus isolates in MDCK cells, differentiated primary human respiratory tract culture, ex-vivo human bronchi tissue and mice. As explained, DAS181 (Fludase) is a sialidase fusion...
- Triple oseltamivir dose resulted in rapid clearance of H1N1. Cox, Amber; Schoen, John; Shafer, Emily // Infectious Disease News;Oct2013, Vol. 26 Issue 10, p21
The article discusses research on the effectiveness of a triple dose of oseltamivir in treating patients with H1N1 influenza A, presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) held in Denver, Colorado on September 10-13, 2013.