TITLE

Complement Factor H Is Expressed in Adipose Tissue in Association With Insulin Resistance

AUTHOR(S)
Moreno-Navarrete, José María; Martínez-Barricarte, Rubén; Catalan, Victoria; Sabater, Mònica; Gómez-Ambrosi, Javier; Ortega, Francisco José; Ricart, Wifredo; Blüher, Mathias; Frühbeck, Gema; de Cordoba, Santiago Rodríguez; Fernández-Real, José Manuel
PUB. DATE
January 2010
SOURCE
Diabetes;Jan2010, Vol. 59 Issue 1, p200
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE--Activation of the alternative pathway of the complement system, in which factor H (fH; complement fH [CFH]) is a key regulatory component, has been suggested as a link between obesity and metabolic disorders. Our objective was to study the associations between circulating and adipose tissue gene expressions of CFH and complement factor B (fB; CFB) with obesity and insulin resistance. RESEARCH DESIGN AND METHODS--Circulating fH and fB were determined by enzyme-linked immunosorbent assay in 398 subjects. CFH and CFB gene expressions were evaluated in 76 adipose tissue samples, in isolated adipocytes, and in stromovascular cells (SVC) (n = 13). The effects of weight loss and rosiglitazone were investigated in independent cohorts. RESULTS--Both circulating fH and fB were associated positively with BMI, waist circumference, triglycerides, and inflammatory parameters and negatively with insulin sensitivity and HDL cholesterol. For the first time, CFH gene expression was detected in human adipose tissue (significantly increased in subcutaneous compared with omental fat). CFH gene expression in omental fat was significantly associated with insulin resistance. In contrast, CFB gene expression was significantly increased in omental fat but also in association with fasting glucose and triglycerides. The SVC fraction was responsible for these differences, although isolated adipocytes also expressed fB and fH at low levels. Both weight loss and rosiglitazone led to significantly decreased circulating fB and fH levels. CONCLUSIONS--Increased circulating fH and fB concentrations in subjects with altered glucose tolerance could reflect increased SVC-induced activation of the alternative pathway of complement in omental adipose tissue linked to insulin resistance and metabolic disturbances. Diabetes 59:200-209, 2010
ACCESSION #
47995266

 

Related Articles

  • Adiponectin: a biomarker of obesity-induced insulin resistance in adipose tissue and beyond. Jin-Ying Lu; Kuo-Chin Huang; Lin-Chau Chang; Ying-Shing Huang; Yu-Chiao Chi; Ta-Chan Su; Chi-Ling Chen; Wei-Shiung Yang // Journal of Biomedical Science;Sep2008, Vol. 15 Issue 5, p565 

    Adiponectin is one of the most thoroughly studied adipocytokines. Low plasma levels of adiponectin are found to associate with obesity, metabolic syndrome, diabetes and many other human diseases. From animal experiments and human studies, adiponectin has been shown to be a key regulator of...

  • Potential effect of insulin resistance and cardiovascular risk factors on metabolic syndrome in subjects with normal fasting plasma glucose levels. Jeong, Dong; Lee, Jeong; Lee, Sangyeoup; Kim, Yun; Bae, Jae; Kim, Dong; Yi, Yu; Cho, Young; Chae, Uisoo // International Journal of Diabetes in Developing Countries;Jun2012, Vol. 32 Issue 2, p75 

    The prevalence of metabolic syndrome has progressively increased with increasing fasting plasma glucose (FPG) levels. This study aimed to investigate the influence of insulin resistance and cardiovascular risk factors on metabolic syndrome in individuals with normal FPG. Study subjects with FPG...

  • Vitamin D and Metabolic Syndrome: Is There a Link? Florentin, Matilda; Elisaf, Moses S.; Mikhailidis, Dimitri P.; Liberopoulos, Evangelos N. // Current Pharmaceutical Design;10/11/2010, Vol. 16 Issue 30, p3417 

    No abstract available.

  • Novel Lipids Targets in the Era of Metabolic Syndrome. Paneni, Francesco; Palano, Francesca; Testa, Marco // High Blood Pressure & Cardiovascular Prevention;Sep2009, Vol. 16 Issue 3, p93 

    During the last decades, the prevalence of obesity, diabetes mellitus and metabolic syndrome (MetS) has dramatically risen in developed countries. A further increase in MetS and diabetes can be anticipated because of projections of a greater prevalence of obesity in the future. Albeit the...

  • Search for the Causal Genes of Obesity-Induced Insulin Resistance by Analyzing the Expression Profile in Human Adipose Tissues. Okazaki, Yukiko; Ueki, Kohjiro; Hara, Kazuo; Horikoshi, Momoko; Kadowaki, Takashi // Diabetes;Jun2007 Supplement 1, Vol. 56, pA286 

    Type 2 diabetes and the metabolic syndrome, are explosively increasing due to a pandemic of obesity. Numerous studies using animal models have suggested that hypertrophied adipocytes by obesity produce a wide variety of adipokines, which may cause and enhance insulin resistance and...

  • Retinol Binding Protein 4 Expression in Humans: Relationship to Insulin Resistance, Inflammation, and Response to Pioglitazone. Aiwei Yao-Borengasser; Varma, Vijayalakshmi; Bodles, Angela M.; Rasouli, Neda; Phanavanh, Bounleut; Lee, Mijeong; Starks, Tasha; Kern, Leslie M.; Spencer, Horace J.; Rashidi, Amir A.; Mcgehee, Robert E.; Fried, Susan K.; Kern, Philip A. // Diabetes;Jun2007 Supplement 1, Vol. 56, pA361 

    Retinol binding protein 4 (RBP4) was overexpressed in adipose tissue of Glut4 KO mice, and elevated RBP4 has been associated with insulin resistance in mouse and human studies. To determine the relationship between RBP4 and obesity, insulin resistance, and other markers of insulin resistance in...

  • Reduction of JNK1 Expression Lowers Adiposity and Improves Insulin Sensitivity in Diet-Induced Obese Mice. Murray, Susan F.; Watts, Lynnetta M.; Booten, Sheri L.; Tokorcheck, Justin W.; Monia, Brett P.; Bhanot, Sanjay; Yu, Xing Xian // Diabetes;Jun2007 Supplement 1, Vol. 56, pA456 

    Studies indicate that the c-Jun N-terminal kinase 1 (JNK1) may act as key mediator of obesity and insulin resistance. JNK1 knockout mice show lower body weight (BW) gain and increased insulin sensitivity when fed a high-fat (HF) diet as compared to wild-type controls. We recently found that...

  • Metabolic syndrome: The 21st century's silent pandemic. Biali, Susan // Alive: Canada's Natural Health & Wellness Magazine;Feb2012, Issue 352, p43 

    No abstract available.

  • Stimulation of lipolysis enhances the rate of cholesterol efflux to HDL in adipocytes. Philip Verghese; Estela Arrese; Jose Soulages // Molecular & Cellular Biochemistry;Aug2007, Vol. 302 Issue 1/2, p241 

    Abstract  Adipose tissue constitutes a major location for cholesterol storage and, as such, it may play a role in the regulation of circulating cholesterol levels. A possible metabolic link between the lipolytic activity of adipocytes and their ability to release cholesterol to...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics