Plasmid pKpQIL encoding KPC-3 and TEM-1 confers carbapenem resistance in an extremely drug-resistant epidemic Klebsiella pneumoniae strain

Leavitt, Azita; Chmelnitsky, Inna; Ofek, Itzhak; Carmeli, Yehuda; Navon-Venezia, Shiri
February 2010
Journal of Antimicrobial Chemotherapy (JAC);Feb2010, Vol. 65 Issue 2, p243
Academic Journal
Objectives: An extremely drug-resistant (XDR) clone of KPC-3-producing Klebsiella pneumoniae emerged in Israel in 2006, causing a nationwide outbreak. We aimed to characterize the local KPC-3-encoding plasmid carried by these isolates and study its contribution to antibiotic resistance.


Related Articles

  • Molecular analysis of population structure and antibiotic resistance of Klebsiella isolates from a three-year surveillance program in Florence hospitals, Italy. Donnarumma, F.; Indorato, C.; Mastromei, G.; Goti, E.; Nicoletti, P.; Pecile, P.; Fanci, R.; Bosi, A.; Casalone, E. // European Journal of Clinical Microbiology & Infectious Diseases;Mar2012, Vol. 31 Issue 3, p371 

    We report the results of a three-year surveillance program of Klebsiella spp. in six hospitals in Florence (Italy). A total of 172 Klebsiella isolates were identified and typed by AFLP: 122 were K. pneumoniae and 50 were K. oxytoca. Most K. pneumoniae (80%) and K. oxytoca (93%) showed unrelated...

  • Carbapenem resistance among Escherichia coli and Klebsiella pneumoniae in a tertiary care hospital in south India. Nagaraj, S.; Chandran, S. P.; Shamanna, P.; Macaden, R. // Indian Journal of Medical Microbiology;Jan2012, Vol. 30 Issue 1, p93 

    Carbapenem resistance among clinical isolates of Enterobacteriaceae, especially Escherichia coli and Klebsiella pneumoniae, is largely conferred by metallo-β-lactamase (MBL). Fifty-one non repetitive isolates of carbapenemresistant (Meropenem and Imipenem) E. coli and K. pneumoniae were...

  • Synergistic activity and effectiveness of a double-carbapenem regimen in pandrug-resistant Klebsiella pneumoniae bloodstream infections. Oliva, Alessandra; D'Abramo, Alessandra; D'Agostino, Claudia; Iannetta, Marco; Mascellino, Maria T.; Gallinelli, Carmela; Mastroianni, Claudio M.; Vullo, Vincenzo // Journal of Antimicrobial Chemotherapy (JAC);Jun2014, Vol. 69 Issue 6, p1718 

    This article reports on three case studies of double-carbapenem regimen in pandrug-resistant Klebsiella pneumoniae bloodstream infections. Topics discussed include the clinical history of the patients, the role of double-carbapenem regimens containing ertapenem, and the synergic activity and...

  • Extended-spectrum β-lactamase and carbapenemase production among burn and non-burn clinical isolates of Klebsiella pneumoniae. Eftekhar, Fereshteh; Naseh, Ziaeldin // Iranian Journal of Microbiology;Jun2015, Vol. 7 Issue 3, p144 

    Background and Objectives: Klebsiella pneumoniae is an opportunistic pathogen responsible for up to 10% of nosocomial infections. The emergence and spread of multidrug resistant K. pneumoniae, mostly due to the production of extended-spectrum β-lactamases (ESBL) and carbapenemases, is often...

  • Containment of a Country-wide Outbreak of Carbapenem-Resistant Klebsiella pneumoniae in Israeli Hospitals via a Nationally Implemented Intervention. Schwaber, Mitchell J.; Lev, Boaz; Israeli, Avi; Solter, Ester; Smollan, Gill; Rubinovitch, Bina; Shalit, Itamar; Carmeli, Yehuda // Clinical Infectious Diseases;Apr2011, Vol. 52 Issue 7, p848 

    During 2006, Israeli hospitals faced a clonal outbreak of carbapenem-resistant Klebsiella pneumoniae, threatening the entire hospital system. A centrally-coordinated nationwide intervention, including isolation of hospitalized carriers, dedicated staffing, and professional oversight, succeeded...

  • An update of the evolving epidemic of blaKPC-2-carrying Klebsiella pneumoniae in Greece (2009–10). Giakkoupi, Panagiota; Papagiannitsis, Costas C.; Miriagou, Vivi; Pappa, Olga; Polemis, Michalis; Tryfinopoulou, Kyriaki; Tzouvelekis, Leonidas S.; Vatopoulos, Alkiviadis C. // Journal of Antimicrobial Chemotherapy (JAC);Jul2011, Vol. 66 Issue 7, p1510 

    Objectives To follow the epidemic of KPC-2-producing Klebsiella pneumoniae in Greece. Methods KPC-2-producing isolates (n = 378) were collected during January 2009–April 2010 in 40 Greek hospitals. blaKPC and blaVIM were detected by PCR. Carbapenemase production was confirmed by...

  • Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant. Liang, Zhongjie; Li, Lianchun; Wang, Yuanyuan; Chen, Limin; Kong, Xiangqian; Hong, Yao; Lan, Lefu; Zheng, Mingyue; Guang-Yang, Cai; Liu, Hong; Shen, Xu; Luo, Cheng; Li, Keqin Kathy; Chen, Kaixian; Jiang, Hualiang // PLoS ONE;2011, Vol. 6 Issue 8, p1 

    The New Delhi Metallo-&bgr;-lactamase (NDM-1) was first reported in 2009 in a Swedish patient. A recent study reported that Klebsiella pneumonia NDM-1 positive strain or Escherichia coli NDM-1 positive strain was highly resistant to all antibiotics tested except tigecycline and colistin. These...

  • EMERGING CARBAPENEM RESISTANCE AMONG NOSOCOMIAL ISOLATES OF KLEBSIELLA PNEUMONIAE IN SOUTH INDIA. Parveen, R. Mohamudha; Harish, B. N.; Parija, S. C. // International Journal of Pharma & Bio Sciences;Apr-Jun2010, Vol. 1 Issue 2, p1 

    Multidrug resistant Klebsiella pneumoniae are an increasingly difficult problem in Indian hospitals. Carbapenems have been the grounding of drug treatment for serious infections caused by these pathogens. Resistance to carbapenems has been unknown until now. The purpose of this study was to...

  • Emergence of OXA-48-producing Klebsiella pneumoniae and the novel carbapenemases OXA-244 and OXA-245 in Spain. Oteo, Jesús; Hernández, Juan Manuel; Espasa, Mateu; Fleites, Ana; Sáez, David; Bautista, Verónica; Pérez-Vázquez, María; Fernández-García, Mª Dolores; Delgado-Iribarren, Alberto; Sánchez-Romero, Isabel; García-Picazo, Luisa; Miguel, Mª Dolores; Solís, Sonia; Aznar, Esteban; Trujillo, Gloria; Mediavilla, Concepción; Fontanals, Dionisia; Rojo, Susana; Vindel, Ana; Campos, José // Journal of Antimicrobial Chemotherapy (JAC);Feb2013, Vol. 68 Issue 2, p317 

    Objectives To describe the molecular and population-level characterization of a selected group of OXA-48-like-producing Klebsiella pneumoniae isolates collected in Spain between January 2011 and May 2012. Methods During the study period, 151 OXA-48-like-producing K. pneumoniae isolates were...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics