Breast Magnetic Resonance Imaging in Patients undergoing Preoperative Systemic Treatment: Current State of Research and Perspectives

Hyeong-Gon Moon; Wonshik Han; Dong-Young Noh
October 2009
Asia Pacific Journal of Oncology & Hematology;2009, Vol. 1 Issue 3, p61
Academic Journal
Preoperative systemic treatment (PST) is now a valuable treatment option for operable breast cancer patients. Its wide use has brought issues of assessing residual disease extent, predicting treatment response, quantitative monitoring of response, and identifying a group of patients with high likelihood of benefit. Breast magnetic resonance imaging (MRI), mostly contrast-enhanced breast MRI, has been suggested as a potential imaging biomarker for the above-mentioned research issues in breast cancer patients undergoing PST. Contrast-enhanced breast MRI has been shown to predict the extent of residual disease with higher accuracy than conventional imaging modalities. However, there have been several reports on factors affecting its accuracy after PST; therefore, the use of breast MRI and the interpretation of the results for patients who received PST should be performed in the context of a multidisciplinary approach. Additionally, this paper also reviews the current status of MRI in predicting chemotherapy responsiveness and various novel MRI technologies that show promise in improving patients care during PST. Initial experiences with novel MRI technologies showed a potential benefit for breast cancer patients undergoing PST. However, a large-scale clinical validation study is needed to confirm the preliminary findings of small pilot evaluations.


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