Infectious canine hepatitis in red foxes (Vulpes vulpes) in the United Kingdom

Thompson, H; O'Keeffe, A. M.; Lewis, J. C. M.; Stocker, L. R.; Laurenson, M. K.; Philbey, A. W.
January 2010
Veterinary Record: Journal of the British Veterinary Association;1/23/2010, Vol. 166 Issue 4, p111
Academic Journal
The pathological findings are described in three cases of infectious canine hepatitis in free-ranging red foxes (Vulpes vulpes) in England. The foxes died after short periods of clinical illness. Mild jaundice and hepatic congestion were evident grossly. On histopathological examination, intranuclear inclusion bodies were visible in hepatocytes, in association with hepatocyte dissociation and necrosis, as well as in renal glomeruli, renal tubular epithelial cells and vascular endothelial cells. Canine adenovirus type 1 (CAV-1) was isolated from all three foxes. In a serological study, antibodies to CAV-1 were detected in tissue fluid extracts taken from 11 of 58 (19 per cent) frozen red fox carcases from England and Scotland.


Related Articles

  • Antilactoferrin Antibodies in Autoimmune Liver Diseases. Ohana, Masaya; Okazaki, Kazuichi; Hajiro, Kiyoshi; Uchida, Kazushige // American Journal of Gastroenterology;Aug1998, Vol. 93 Issue 8, p1334 

    Objective: Lactoferrin, an immunoregulatory protein in mucosal secretions, is one of the target antigens to perinuclear antincutrophil cytopiasmic antibodies (P-ANCAs). Circulating lactoferrin is cleared in the liver, but little is known about the implication of lactoferrin in hepatic...

  • Spontaneous Clearance of Chronic Hepatitis C Virus Infection Is Associated With Appearance of Neutralizing Antibodies and Reversal of T-Cell Exhaustion. Raghuraman, Sukanya; Park, Heiyoung; Osburn, William O.; Winkelstein, Emily; Edlin, Brian R.; Rehermann, Barbara // Journal of Infectious Diseases;3/1/2012, Vol. 205 Issue 5, p763 

    Background. Hepatitis C virus (HCV) readily establishes chronic infection with exhaustion of HCV-specific T cells and escape from neutralizing antibodies. Spontaneous recovery from chronic infection is rare and has never to our knowledge been studied immunologically. Methods. We prospectively...

  • The GB Virus C/Hepatitis G Virus Replicates in Hepatocytes without Causing Liver Disease in Healthy Blood Donors. Halasz, Robert; Sallberg, Matti; Lundholm, Suzana; Andersson, Goran; Lager, Bjorn; Glaumann, Hans; Weiland, Ola // Journal of Infectious Diseases;12/1/2000, Vol. 182 Issue 6 

    Thirty-seven persons were identified with GB virus C (GBV-C) single infection by polymerase chain reaction screening of 1254 healthy blood donors. Of 33 donors who returned for clinical examination, 17 underwent liver biopsy. Clinical, biochemical, and histologic evaluation did not reveal any...

  • Clinical Significance of Autoantibody to Hepatocyte Membrane Antigen in Type 1 Autoimmune Hepatitis. Sasaki, Mina; Yamauchi, Katsumi; Tokushige, Katsutoshi; Isono, Etsuko; Komatsu, Tatsuji; Zeniya, Mikio; Toda, Gotaro; Hayashi, Naoaki // American Journal of Gastroenterology;Mar2001, Vol. 96 Issue 3, p846 

    OBJECTIVE: By using HepG2 as flow cytometry target, we have reported that autoantibody to hepatocyte membrane antigen (anti-HMA) was frequently found in autoimmune hepatitis (AIH) patients. In this study, we have examined this autoantibody in relation to clinical features in these patients....

  • TGF-β DEPENDENT HEPATOCYTES TRANSDIFFERENTIATION IN ALCOHOL-INDUCED HEPATIC FIBROSIS. Ciuclan, Loredana; Brietkopf, Katja; Singer, M. V.; Dooley, S. // Analele Societatii Nationale de Biologie Celulara;2008, Vol. 13, p19 

    The pathophysiological steps leading to distruction of liver architecture are highly complex and multifactorial. Different levels in hepatic injury comprise steatosis, steatohepatitis with fobrosis, cirrhosis and hepatocelular carcinoma. Profibrogenic TGF-β action has mostly been attributed...

  • Distribution of Hepatic Myofibroblasts and Type I and III Collagen in Rat Liver Cirrhosis Induced by Thioacetamide. Poonkhum, Raksawan; Pradidarcheep, Wisuit; Nilbu-Nga, Somneuk; Chaunchaiyakul, Suwadee // International Journal of Morphology;2011, Vol. 29 Issue 2, p501 

    Thioacetamide (TAA) can induce various types of cirrhosis in the rat, including bridging fibrosis, biliary fibrosis, perisinusoidal/pericellular fibrosis and centrilobular fibrosis, in which different populations of hepatic myofibroblasts (MFs) are involved. The hepatic MFs can be classified...

  • Longitudinal evaluation of hepatitis C viral persistence in HIV-infected patients with spontaneous hepatitis C clearance. Rivero-Juarez, A.; Caruz, A.; Real, L.; Martinez-Dueñas, L.; Marquez, F.; Frias, M.; Recio, E.; Gordon, A.; Pineda, J.; Rivero, A.; Camacho, A. // European Journal of Clinical Microbiology & Infectious Diseases;Nov2015, Vol. 34 Issue 11, p2171 

    Hepatitis C virus (HCV) viral persistence in patients with spontaneous viral clearance is controversial. Several studies have shown HCV-RNA in peripheral blood mononuclear cells (PBMCs) and/or liver tissue among patients who have cleared the virus spontaneously, suggesting that viral persistence...

  • Hepatitis C Virus Clearance: The Enigma of Failure Despite an Impeccable Survival Strategy. M.G. Isaguliants // Current Pharmaceutical Biotechnology;Jun2003, Vol. 4 Issue 3, p169 

    Infection with human hepatitis C virus (HCV) as a result of a bilateral process of host-virus interactions. There are factors on both sides that contribute to clearance and to chronicity. Virus strategy to survive is built on several basic features. The first, recently recognized, is a wide cell...

  • Autoantibodies to hepatocyte plasma membrane antigens in autoimmune hepatitis: old and new subjects; what do we need? Zeniya, Mikio // Journal of Gastroenterology;2000, Vol. 35 Issue 3, p252 

    Editorial. Introduces a research paper on the autoimmune reactivity of sera to hepatocyte plasma membrane in type 1 autoimmune hepatitis, published in the March 2000 issue of the `Journal of Gastroenterology.'


Read the Article


Sign out of this library

Other Topics