Pericardial fat is more abundant in patients with coronary atherosclerosis and even in the non-obese patients: evaluation with cardiac CT angiography

Hwan Seok Yong; Eung Ju Kim; Hong Seog Seo; Eun-Young Kang; Yun Kyung Kim; Ok Hee Woo; Heon Han
February 2010
International Journal of Cardiovascular Imaging;Feb2010 Supplement 1, Vol. 26, p53
Academic Journal
Epicardial adipose tissue (EAT) may play an important role for developing an unfavorable cardiovascular risk profile. However, it has not been investigated if EAT is associated with coronary atherosclerosis in non-obese patients. We aimed to evaluate whether EAT is related to coronary atherosclerosis in non-obese patients. Among the consecutive patients who underwent coronary CT angiography (CCTA) with an intermediate pretest likelihood for having coronary artery disease, we excluded the patients whose body mass index (BMI) was over 30 kg/m2 or whose CCTA image quality was not sufficient for the detection of coronary plaque. The remaining patients were divided into the normal and abnormal groups based on the presence of atherosclerotic plaques as seen on the CCTA images. The cardiovascular risk factors were matched between the two groups. Ultimately, 100 patients were included in the normal group and 100 patients were included in the abnormal group. The pericardial fat area was measured at the subaortic level of the heart on the axial CT images. The pericardial fat area was significantly larger in the abnormal group as compared to the normal group (18.1 ± 10.2 vs. 14.6 ± 8.7 cm2, P = 0.019). Even though the overweight patients (25 ≤ BMI < 30) were excluded, the pericardial fat area was still significantly larger in the patients with coronary atherosclerotic plaque as compared to that of the patients without coronary atherosclerotic plaque (18.7 ± 11.5 vs. 13.2 ± 7.9 cm2, P = 0.006). Pericardial fat was more abundant in the non-obese patients with coronary atherosclerosis as compared to that of the patients without coronary atherosclerosis, after controlling for the other cardiovascular risk factors.


Related Articles

  • Visceral adipose tissue area is associated with coronary stenosis and noncalcified plaques. Kang, S J; Kim, D; Park, H E; Choi, S H; Choi, S-Y; Lee, W; Kim, J S; Cho, S-H // International Journal of Obesity;Feb2014, Vol. 38 Issue 2, p272 

    Objective:Few studies have investigated the relationships between visceral adipose tissue (VAT) and coronary stenosis and noncalcified plaques at the subclinical stage. The aim of this study was to investigate relationship between VAT and coronary lesions assessed by coronary computed tomography...

  • An indicator of subclinical cardiovascular disease in patients with primary osteoarthritis: epicardial fat thickness. Belen, Erdal; Ozgur Karaman; Caliskan, Gurkan; Atamaner, Oya; Aslan, Omer // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 6, p9491 

    Osteoarthritis (OA) is one of the most common chronic diseases seen in the elderly, and it is associated with increased cardiovascular morbidity and mortality. The cause of this association is not fully known. We aimed to investigate the relationship between epicardial fat and the presence and...

  • The fat scan study: correlation of visceral adipose tissue to coronary atherosclerosis in a multi-ethnicity Australian population. Binny, S.; Dahiya, A.; Challa, P.; Hardman, D.; Jeffries, C. // Heart, Lung & Circulation;2015 Supplement 3, Vol. 24, pS168 

    No abstract available.

  • Implications of Pericardial, Visceral and Subcutaneous Adipose Tissue on Vascular Inflammation Measured Using 18FDG-PET/CT. Hong, Ho Cheol; Hwang, Soon Young; Park, Soyeon; Ryu, Ja Young; Choi, Hae Yoon; Yoo, Hye Jin; Seo, Ji-A; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei Hyun; Choi, Dong Seop; Kim, Sungeun; Choi, Kyung Mook // PLoS ONE;8/13/2015, Vol. 10 Issue 8, p1 

    Objective: Pericardial adipose tissue (PAT) is associated with adverse cardiometabolic risk factors and cardiovascular disease (CVD). However, the relative implications of PAT, abdominal visceral and subcutaneous adipose tissue on vascular inflammation have not been explored. Method and...

  • Contribution of Genetic and Metabolic Syndrome to Omental Adipose Tissue PAI-1 Gene mRNA and Plasma Levels in Obesity. Bouchard, Luigi; Vohl, Marie-Claude; Lebel, Stéfane; Hould, Frédéric-Simon; Marceau, Picard; Bergeron, Jean; Pérusse, Louis; Mauriège, Pascale // Obesity Surgery;Apr2010, Vol. 20 Issue 4, p492 

    Plasminogen activator inhibitor type-1 (PAI-1) has already been associated with atherosclerosis; myocardial infarction; and cardiovascular disease risk factors such as obesity, insulin resistance, and dyslipidemia. However, factors regulating PAI-1 adipose tissue (AT) gene expression and plasma...

  • More risk factors mean more severe CAD in the young as well as the old.  // Modern Medicine;Aug98, Vol. 66 Issue 8, p12 

    Presents an abstract of the article `Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults,' by G.S. Berenson, S.R. Srinivasa, W. Bao, et al, from the `New England Journal of Medicine' dated June 4, 1998.

  • Distribution of Abdominal Adiposity and Cardiovascular Risk Factors in Yaquis Indians from Sonora, México. Olga Brito-Zurita; Alberto Domínguez-Banda; Víctor Ugalde-Aguirre; Ana Cortez-Valenzuela; Rosa Villanueva-Pérez; Martha Rodríguez-Morán; Fernando Guerrero-Romero // Metabolic Syndrome & Related Disorders;Dec2007, Vol. 5 Issue 4, p353 

    BackgroundStudies on adiposity in indigenous populations from Mexico are scarce and there are not previous reports that examine the topography of abdominal fat depot and cardiovascular risk factors. Therefore, we determined the distribution of abdominal subcutaneous adipose tissue (SAT) and...

  • Epicardial Fat and Its Association with Cardiovascular Risk: A Cross-Sectional Observational Study. Mookadam, Farouk; Goel, Ramil; Alharthi, Mohsen S.; Jiamsripong, Panupong; Cha, Stephen // Heart Views;Oct-Nov2010, Vol. 11 Issue 3, p103 

    Background: The association between visceral obesity and cardiovascular risk has been well described. Some studies show a proportional relationship between the presence of visceral obesity and epicardial fat. Measuring the amount of epicardial adipose tissue (EAT) can be a novel parameter that...

  • Bad Belly.  // Nutrition Action Health Letter;Oct2013, Vol. 40 Issue 8, p8 

    The article discusses the health risk of larger visceral fat and obesity which could cardiovascular disease and breast and colorectal cancers.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics