Note: Interference technique for minimally invasive, subnanometer, microsecond measurements of displacements

Dujovne, Irene; Kerssemakers, Jacob; Cappello, G.; Dekker, Cees
January 2010
Review of Scientific Instruments;Jan2010, Vol. 81 Issue 1, p016103
Academic Journal
We present a novel high-resolution technique for single-molecule experiments, viz., differential traveling wave tracking. This is an interference-based scattering technique where we use gold nanoparticles for high scattering intensities and incorporate differential measurements along one in-plane direction to subtract mechanical noise and drift of the system. In addition, out-of-plane distances are measured via scattered light intensity in a total internal reflectance illumination field. In plane, we demonstrate a rms noise level of only 0.10 nm at 10 kHz and less than 0.5 nm at 600 kHz.


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