In vitro antibacterial activity of some systemic and topical antihistaminic preparations

Julide Sedef Gocmen; Unase Buyukkocak; Osman Caglayan
December 2009
Clinical & Investigative Medicine;Dec2009, Vol. 32 Issue 6, pE232
Academic Journal
In vitro antibacterial activity of topical and systemic antihistaminic preparations containing different active substrates against the standard strains of two bacteria was evaluated. Methods: Four topical and 3 systemic preparations containing pheniramine maleate, chlorophenoxamine hydrochloride, and diphenhydramine hydrochloride were studied. The antibacterial activities of these preparations against strains of S. aureus (American Type Culture Collection, ATCC 29213) and S. epidermidis (ATCC 25212) were tested using the disc diffusion method. In addition, the Minimal Innhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) of parenteral preparations for these two bacteria were determined. Results: Pheniramine maleate-topical and pheniramine maleate-systemic had no activity against bacteria, but the others showed various rates of activity. Chlorophenoxamine hydrochloride-topical and phlorophenoxamine hydrochloride-systemic were the most effective (P < 0.05). Despite the same active substrate content, diphenhydramine hydrochloride-topical-1 and diphenhydramine hydrochloride-topical-2 yielded different results when they were compared with each other or with the other preparations. Diphenhydramine hydrochloride-topical-2 had a relatively higher rate of activity than diphenhydramine hydrochloride-topical-1. Inhibition zone diameters were 16.9±1.5 mm 12.3±0.5 mm for S .aureus, 17.4±1.0 mm 0 mm for S .epidermidis respectively (P < 0.05). MIC values of parenteral preparations were equal to or above 125 μg/ml. Conclusion:, MIC values of parenteral preparations were higher than their blood levels in clinical use. Thus, effects of parenteral preparations may not have been reflected in routine clinical practice. However, topical forms have antibacterial activity due to additive substrates and the use of high concentration levels at the site of application. Therefore, in selection of topical forms for appropriate cases, these effects should also be taken into consideration. The antibacterial activity of topical antihistaminic preparations may be useful in certain dermatological pathology.


Related Articles

  • Treatment of pruritus due to chronic obstructive liver disease. Duncan, J.S.; Kennedy, H.J.; Triger, D.R. // British Medical Journal (Clinical Research Edition);7/7/1984, Vol. 289 Issue 6436, p22 

    Compares the effectivity of different antipruritic drugs. List of antipruritic drugs; Enumeration of the effects of each drug; Finding of benefiting best from cholestyramine and terfenadine.

  • Pictorial case study - A well-defined pink lesion. Watkins, Jean // GP: General Practitioner;11/11/2013, p16 

    The article describes the case of pityriasis rosea in a young man. The patient initially presented slightly itchy lesions on his chest that developed into symmetrically distributed lesions. Results of the physical and clinical examination of his skin condition are reported. While there is no...

  • High antimicrobial resistance among bacterial isolates of blood stream infections (BSI) in a Nigerian University Teaching Hospital. Samuel Taiwo; Solomon Fadiora; Samuel Fayemiwo // World Journal of Microbiology & Biotechnology;Feb2008, Vol. 24 Issue 2, p231 

    Abstract  The antimicrobial resistance profile of 220 bacteria isolated from 1,006 episodes of blood stream infections (BSI) between January 2004 and December 2005 in a University Teaching Hospital, Southwestern Nigeria, were analyzed. Gram positive bacteria constituted 47.3%...

  • Treatment with antibacterials gets the 'tick' when treating skin mainfestation of Lyme disease.  // Drugs & Therapy Perspectives;Jul2009, Vol. 25 Issue 7, p17 

    The article focuses on the use of antibacterial agents in treating the skin manifestations of the patients with Lyme disease. It states that Lyme disease is a multisystem infectious condition that can be transmitted to humans through the tick bites of Borrelia burgdorferi. The use of...

  • TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Wilson, Sarah R.; Gerhold, Kristin A.; Bifolck-Fisher, Amber; Liu, Qin; Patel, Kush N.; Dong, Xinzhong; Bautista, Diana M. // Nature Neuroscience;May2011, Vol. 14 Issue 5, p595 

    Itch, the unpleasant sensation that evokes a desire to scratch, accompanies numerous skin and nervous system disorders. In many cases, pathological itch is insensitive to antihistamine treatment. Recent studies have identified members of the Mas-related G protein-coupled receptor (Mrgpr) family...

  • Paracetamol/pheniramine/ascorbic acid.  // Reactions Weekly;10/3/2009, Issue 1272, p25 

    The article reports on the case of a 54-year-old man who developed a circular, erythematous and oedematous cutaneous skin eruption on his glans penis 3 days after taking paracetamol (acetaminophen)/pheniramine/ascorbic-acid under the brand name Fervex for nasal congestion. The same effect...

  • CONJUNCTIVITIS.  // Pulse;1/28/2009, Vol. 69 Issue 2, p36 

    The article highlights the symptoms, diagnosis and treatment of conjunctivitis. It notes that itching, discharge from the eyes and feeling of a foreign body are the symptoms of conjunctivitis. On the other hand, its treatment includes ointment that contains fucidinic acid, chloramphenicol drops...

  • Cefpodoxime.  // Reactions Weekly;3/22/2008, Issue 1194/1195, p12 

    This article describes the case of a 40-year-old woman who developed a generalized maculopapular cutaneous eruption after receiving cefpodoxime for an acute upper respiratory tract infection. An overview of the patient's medical history is provided. The results of the physical and laboratory...

  • Health q&a. Callahan, Lisa // Self;Apr2005, Vol. 27 Issue 4, p155 

    Presents the question and answer advisory related to health. Characteristics of overactive bladder; Concept of an exercise-induced asthma; Importance of covering a wound.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics