Carboplatin-mediated changes in the activity levels of steroidogenic marker enzymes, serum hormones and testicular architecture in male rats

Reddy, Y. V. Kishore; Reddy, P. Sreenivasula; Shivalingam, M. R.; Devi, B. Suvarchala; Pravallika, G.; Anusha, D. Naga
January 2010
Drug Invention Today;Jan2010, Vol. 2 Issue 1, p42
Academic Journal
Carboplatin (10 mg/ kg body weight) caused significant decrease in the activity levels of steroidogenic marker enzymes such as 3β-hydroxy steroid dehydrogenase and 17β-hydroxy steroid dehydrogenase in experimental rats when compared to that of the control rats. In addition, activity levels of serum hormones including LH, FSH and Testosterone were also altered significantly in experimental animals. Besides, causing significant alterations in the activity levels of steroidogenic marker enzymes, and serum hormones, carboplatin treatment also caused changes in testicular architecture in rats.


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