TITLE

A dielectric affinity microbiosensor

AUTHOR(S)
Xian Huang; Siqi Li; Schultz, Jerome S.; Qian Wang; Qiao Lin
PUB. DATE
January 2010
SOURCE
Applied Physics Letters;1/18/2010, Vol. 96 Issue 3, p033701
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We present an affinity biosensing approach that exploits changes in dielectric properties of a polymer due to its specific, reversible binding with an analyte. The approach is demonstrated using a microsensor comprising a pair of thin-film capacitive electrodes sandwiching a solution of poly(acrylamide-ran-3-acrylamidophenylboronic acid), a synthetic polymer with specific affinity to glucose. Binding with glucose induces changes in the permittivity of the polymer, which can be measured capacitively for specific glucose detection, as confirmed by experimental results at physiologically relevant concentrations. The dielectric affinity biosensing approach holds the potential for practical applications such as long-term continuous glucose monitoring.
ACCESSION #
47680125

 

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