An underlap field-effect transistor for electrical detection of influenza

Kwang-Won Lee; Sung-Jin Choi; Jae-Hyuk Ahn; Dong-Il Moon; Park, Tae Jung; Sang Yup Lee; Yang-Kyu Choi
January 2010
Applied Physics Letters;1/18/2010, Vol. 96 Issue 3, p033703
Academic Journal
An underlap channel-embedded field-effect transistor (FET) is proposed for label-free biomolecule detection. Specifically, silica binding protein fused with avian influenza (AI) surface antigen and avian influenza antibody (anti-AI) were designed as a receptor molecule and a target material, respectively. The drain current was significantly decreased after the binding of negatively charged anti-AI on the underlap channel. A set of control experiments supports that only the biomolecules on the underlap channel effectively modulate the drain current. With the merits of a simple fabrication process, complementary metal-oxide-semiconductor compatibility, and enhanced sensitivity, the underlap FET could be a promising candidate for a chip-based biosensor.


Related Articles

  • Simulation of Field-Effect Biosensors (BioFETs) for Biotin-Streptavidin Complexes. Windbacher, Thomas; Sverdlov, Viktor; Selberherr, Siegfried; Heitzinger, Clemens; Mauser, Norbert; Ringhofer, Christian // AIP Conference Proceedings;1/4/2010, Vol. 1199 Issue 1, p507 

    Biologically sensitive field-effect transistors (BioFETs) are a promising technology for detecting pathogens, antigen-antibody complexes, and tumor markers. A BioFET is studied for a biotin-streptavidin complex. Biotin-streptavidin is used in detection and purification of various biomolecules....

  • Expression and Characterization of Hepatitis B Surface Antigen in Transgenic Potato Plants. Shulga, N. Ya.; Rukavtsova, E. B.; Krymsky, M. A.; Borisova, V. N.; Melnikov, V. A.; Bykov, V. A.; Buryanov, Ya. I. // Biochemistry (00062979);Oct2004, Vol. 69 Issue 10, p1158 

    Transgenic potato plants expressing the gene of hepatitis B surface antigen (HBsAg) under the control of the double promoter of 35S RNA of cauliflower mosaic virus (CaMV 35SS) and the promoter of patatin gene of potato tubers have been obtained. Biochemical analysis of the plants was performed....

  • Providing ligands for MHC class I molecules. Endert, Peter // Cellular & Molecular Life Sciences;May2011, Vol. 68 Issue 9, p1467 

    No abstract available.

  • Intracellular transport routes for MHC I and their relevance for antigen cross-presentation. Adiko, Aimé Cézaire; Babdor, Joel; Gutiérrez-Martínez, Enric; Guermonprez, Pierre; Saveanu, Loredana // Frontiers in Immunology;Jul2015, p1 

    Cross-presentation, in which exogenous antigens are presented via MHC I complexes, is involved both in the generation of anti-infectious and anti-tumoral cytotoxic CD8+ T cells and in the maintenance of immune tolerance. While cross-presentation was described almost four decades ago and while it...

  • T-cell Intracellular Antigen (TIA)-Proteins Deficiency in Murine Embryonic Fibroblasts Alters Cell Cycle Progression and Induces Autophagy. Sánchez-Jiménez, Carmen; Izquierdo, José M. // PLoS ONE;Sep2013, Vol. 8 Issue 9, p1 

    Mice lacking either T-cell intracellular antigen 1 (TIA1) or TIA1 related/like protein (TIAR/TIAL1) show high rates of embryonic lethality, suggesting a relevant role for these proteins during embryonic development. However, intrinsic molecular and cellular consequences of either TIA1 or TIAR...

  • Molecular Characterization of a New Babesia bovis Thrombospondin-Related Anonymous Protein (BbTRAP2). Terkawi, Mohamad Alaa; Ratthanophart, Jadsada; Salama, Akram; AbouLaila, Mahmoud; Asada, Masahito; Ueno, Akio; Alhasan, Hend; Guswanto, Azirwan; Masatani, Tatsunori; Yokoyama, Naoaki; Nishikawa, Yoshifumi; Xuan, Xuenan; Igarashi, Ikuo // PLoS ONE;Dec2013, Vol. 8 Issue 12, p1 

    A gene encoding a Babesia bovis protein that shares significant degree of similarity to other apicomplexan thrombospondin-related anonymous proteins (TRAPs) was found in the genomic database and designated as BbTRAP2. Recombinant protein containing a conserved region of BbTRAP2 was produced in...

  • Genetically Controlled Expression of Surface Variant Antigens in Free-Living Protozoa. Kusch, J.; Schmidt, H.J. // Journal of Membrane Biology;Mar2001, Vol. 180 Issue 2, p101 

    Describes the genetically controlled expression of surface variant antigens in free-living protozoa. Ability of some free-living ciliates to exhibit alternative types of proteins on their cell surface; Utilization of immunochemical techniques; Expression of one type of surface antigen at...

  • The Wide Bandgap Bandwagon. Lecklider, Tom // EE: Evaluation Engineering;Jul2012, Vol. 51 Issue 7, p8 

    The article discusses the future of wide-bandgap devices with silicon carbide (SiC) rectifiers. According to Jimmy Yeh, director of strategic marketing at GE Aviation Systems, SiC is expected to play a major role in reducing weight and improving reliability, but challenges linked to the yield...

  • Molecular characterization of novel trispecific ErbB-cMet-IGF1R antibodies and their antigen-binding properties. Castoldi, R.; Jucknischke, U.; Pradel, L.P.; Arnold, E.; Klein, C.; Scheiblich, S.; Niederfellner, G.; Sustmann, C. // PEDS: Protein Engineering, Design & Selection;Oct2012, Vol. 25 Issue 10, p551 

    Therapeutic antibodies are well established drugs in diverse medical indications. Their success invigorates research on multi-specific antibodies in order to enhance drug efficacy by co-targeting of receptors and addressing key questions of emerging resistance mechanisms. Despite challenges in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics