TITLE

Thyroid hormone and cortisol concentrations after congenital heart surgery in infants younger than 3 months of age

AUTHOR(S)
Plumpton, Kevin R.; Anderson, Brian J.; Beca, John
PUB. DATE
February 2010
SOURCE
Intensive Care Medicine;Feb2010, Vol. 36 Issue 2, p321
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To investigate associations between thyroid hormone and cortisol concentrations after cardiac surgery and postoperative intensive care course. Prospective observational study of 52 infants <3 months of age following congenital heart surgery. Infants with low tri-iodothyronine (≤3.7 pmol/l) or high cortisol concentration on postoperative admission to the paediatric intensive care unit (PICU) were more likely to have a high inotrope requirement on postoperative day 2 ( p = 0.003 and p = 0.0006, respectively) or need mechanical ventilation for longer than 96 h ( p = 0.04 and p = 0.002, respectively). Total cortisol concentration < 200 nmol/l was found in 16 (31%) infants. There was no association between low cortisol and postoperative complications. Infants <3 months of age with low tri-iodothyronine or high cortisol concentration on PICU admission have a more complicated PICU course. Low cortisol concentration is common in the early postoperative period, but is not associated with postoperative complications.
ACCESSION #
47626588

 

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