Early physiological and biological features in three animal models of induced acute lung injury

López-Aguilar, Josefina; Quilez, María Elisa; Martí-Sistac, Octavi; García-Martín, Carolina; Fuster, Gemma; Puig, Ferranda; Flores, Carlos; Villar, Jesús; Artigas, Antonio; Blanch, Lluís
February 2010
Intensive Care Medicine;Feb2010, Vol. 36 Issue 2, p347
Academic Journal
Critically ill patients often develop acute lung injury (ALI) in the context of different clinical conditions. We aimed to explore differences in early local and systemic features in three experimental animal models of ALI. Mechanically ventilated male Sprague–Dawley rats were randomized to high tidal volume (VT) ventilation (HVT) ( n = 8, VT 24 ml/kg), massive brain injury (MBI) ( n = 8, VT 8 ml/kg) or endotoxemia (LPS) ( n = 8, VT 8 ml/kg). Each experimental group had its own control group of eight rats (VT 8 ml/kg). We measured arterial blood gases, mean arterial pressure, lung compliance, inflammatory mediators in plasma and their expression and gelatinase activity in the lungs after 3 h of injury. Despite maintaining relatively normal lung function without evidence of important structural changes, we observed altered lung and systemic inflammatory responses in all three experimental models. LPS triggered the most robust inflammatory response and HVT the lowest systemic proinflammatory response. The HVT group had higher Il6, Tnf and Cxcl2 mRNA in lungs than MBI animals. Metalloproteinase activity/expression and neutrophilic recruitment in the lungs were higher in HVT than in LPS or MBI. The early responses to direct or remote lung insult in our three models of ALI captured different physiological and biological features that could lead to respiratory and/or multiorgan failure.


Related Articles

  • When do you cut off care in the ICU?  // Trustee;Feb96, Vol. 49 Issue 2, p4 

    Reports on the study on intensive care patients at Stanford University Hospital in Stanford, California. Identification of patients least likely to benefit from typical intensive care treatments; Characteristics of patients included in the Potential Ineffective Care category.

  • CME/CNE Questions.  // Critical Care Alert;Jun2007, Vol. 15 Issue 3, p23 

    A quiz related to critical care medicine is presented.

  • CE Test.  // Critical Care Nurse;Apr2010 Supplement, pS17 

    The article presents a continuing education (CE) test related to progressive mobility in the critically ill.

  • An emotional awakening. Heras La Calle, Gabriel // Intensive Care Medicine;Jan2016, Vol. 42 Issue 1, p115 

    A personal narrative is presented which explores the author's experience of being an intensive care physician since 2007 where he worked daily with the critically ill and their families.

  • Assessing intensive care. Lowry, Stella // BMJ: British Medical Journal (International Edition);5/6/89, Vol. 298 Issue 6682, p1205 

    Evaluates intensive care in Great Britain. Disadvantages of intensive care units for patients; Guidelines for the management of intensive care units; Criteria for the admission to intensive care units.

  • Increased Mortality Associated with Growth Hormone Treatment in Critically Ill Adults. Takala, Jukka; Ruokonen, Esko; Webster, Nigel R.; Nielsen, Michael S.; Zandstra, Durk F.; Vundelinckx, Guy; Hinds, Charles J. // New England Journal of Medicine;09/09/99, Vol. 341 Issue 11, p785 

    Background: The administration of growth hormone can attenuate the catabolic response to injury, surgery, and sepsis. However, the effect of high doses of growth hormone on the length of stay in intensive care and in the hospital, the duration of mechanical ventilation, and the outcome in...

  • Is continuous infusion ceftriaxone better than once-a-day dosing in intensive care? A randomized controlled pilot study. Jason A. Roberts; Rob Boots; Claire M. Rickard; Peter Thomas; Jo Quinn; Darren M. Roberts; Brent Richards; Jeffrey Lipman // Journal of Antimicrobial Chemotherapy (JAC);Feb2007, Vol. 59 Issue 2, p285 

    Objectives: To compare the clinical and bacteriological outcome of critically ill patients with sepsis treated by ceftriaxone administered as a once-a-day intermittent bolus dose or by 24 h continuous infusion. Patients and methods: We conducted an open-label, randomized...

  • care, intensive.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p372 

    A definition of the term "intensive care" is presented.

  • The role of the intensive care unit in the management of the critically ill surgical patient. Cuthbertson, Brian H.; Webster, Nigel R. // Journal of the Royal College of Surgeons of Edinburgh;Oct99, Vol. 44 Issue 5, p294 

    Examines the role of the intensive care unit in the management of the critically ill surgical patient in Great Britain. Intensive care versus high dependency care; Criteria for intensive care admission; Pre-operative admission; Early recognition and intervention; Role of the intensive care unit...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics