TITLE

Early changes in contractility indices and fibrosis in two minimally invasive congestive heart failure models

AUTHOR(S)
de Souza Vilarinho, Karlos Alexandre; Petrucci, Orlando; Baker, R. Scott; Vassallo, José; Schenka, André Almeida; Duffy, Jodie Y.; de Oliveira, Pedro Paulo Martins; Vieira, Reinaldo Wilson
PUB. DATE
February 2010
SOURCE
European Journal of Cardio-Thoracic Surgery;Feb2010, Vol. 37 Issue 2, p368
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract: Background: Heart failure is a common and often fatal disease. Numerous animal models are used to study its aetiology, progression and treatment. This article aims to demonstrate two minimally invasive models of congestive heart failure in a rabbit model and a precise method to assess cardiac performance. Methods: Fifty New Zealand White rabbits underwent cervicotomy incision and were then divided into three groups. Aortic regurgitation (AR group) was induced in 17 animals by catheter lesion through the right carotid artery, proximal aortic constriction (AC group) was created in 17 animals by metallic clip placement in the ascending aorta through a neck incision, while 16 animals served as controls (CO group). Eight weeks later, myocardial function and contractility indices were assessed by sonomicrometry crystals. Hearts were then collected for morphometric measurements and left ventricular tissues were subjected to immunohistochemical analysis of fibrosis, necrosis and apoptosis. Statistical analysis was by analysis of variance (ANOVA) with a Dunnett''s post hoc test or by Kruskal–Wallis test with Dunn''s post hoc test as appropriate, with significance at p ≤0.05. Results: The model of aortic regurgitation indicated early stages of heart failure by volume overload with increased end-diastolic and end-systolic volumes, stroke volume, cardiac output and pressure–volume loop areas. The elastance was higher in the control group compared with that in the AC and AR groups (131.00±51.27 vs 88.77±40.11 vs 75.29±50.70; p =0.01). The preload recruitable stroke work was higher in the control group compared with that in the AC and AR groups (47.70±14.19 vs 33.87±7.46 vs 38.58±9.45; p =0.01). Aortic constriction produced left ventricular concentric hypertrophy. Fibrosis appeared in both heart failure models and was elevated by aortic constriction when compared with that in controls. Necrosis and apoptosis indices were very low in all the groups. Clinical signs of congestive heart failure were not present. Conclusions: The two heart failure models we describe were relatively simple to create and maintain, minimally invasive, accurate, inexpensive and, importantly, had a low mortality rate. These models rapidly induced deterioration of contractility indices and onset of fibrosis, the hallmarks of early myocardial dysfunction associated with heart failure. Sonomicrometry assessments were able to detect early contractility changes prior to clinical signs.
ACCESSION #
47610542

 

Related Articles

  • Calcified giant congenital non-coronary sinus Valsalva aneurysm ruptured into the left ventricular outflow tract. Özcan, Ali Vefa; Evrengül, Harun; Gokşin, İbrahim; Önem, Gokhan // Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi;Dec2007, Vol. 7 Issue 4, pE2 

    The article presents the case study of a 42-year-old man admitted to the hospital with six-month history of congestive heart failure (NYHA II). Transesophageal echocardiography (TEE), computed tomography (CT) and angiography reveal calcified giant sinus Valsalva aneurysm (ASV). Also, aortic...

  • Abstracts of the 11th Annual SCMR Scientific Sessions -- 2008.  // Journal of Cardiovascular Magnetic Resonance (BioMed Central);2008 Supplement 1, Vol. 10, p1 

    The article presents abstracts related to cardiovascular magnetic resonance (CMR) which include the prognostic significance of post-procedural irreversible myocardial injury detected by CMR imaging, quantifying aortic regurgitation with CMR and prediction of patients requiring aortic valve...

  • Aortico-left ventricular tunnel. Kondrachuk, Oleksandr; Yemets, Illya // Pediatric Radiology;Dec2008, Vol. 38 Issue 12, p1353 

    The article discusses aortico-left ventricular tunnel, a very rare congenital anomaly, in a 3-day-old boy. The boy was referred to hospital because of severe congestive heart failure and severe aortic incompetence. He underwent aortico-left ventricular repair and the postoperative course was...

  • Anesthetic management of aortocaval fistula repair associated with aortic valve replacement, severe aortic regurgitation, and bacterial endocarditis. Porhomayon, Jahan; Hassan, Mahmoud A. A.; Perala, Padmavathi R.; Nader, Nader D. // Journal of Anesthesia;2011, Vol. 25 Issue 2, p263 

    We report a case of an adult male who had received a gunshot to the abdomen 12 years earlier. He presented with manifestations of high-output congestive heart failure (CHF), aortic regurgitation (AR), and pulmonary septic embolism. Further investigation revealed an aortocaval fistula (ACF)....

  • Cardiac Effects on Peripheral Vascular Doppler Waveforms. Bendick, Phillip J. // Journal for Vascular Ultrasound;Dec2011, Vol. 35 Issue 4, p237 

    In the aging patient population seen routinely in the noninvasive vascular laboratory, the possibility of Doppler waveform abnormalities secondary to cardiac effects, rather than localized obstructive disease, should be kept in mind. These abnormalities present in a variety of ways in both the...

  • When is surgery indicated for infectious endocarditis?  // Patient Care for the Nurse Practitioner;Jun2004, Vol. 7 Issue 6, p8 

    The article reveals surgical interventions recommended in infectious endocarditis (IE). The conditions include moderate or severe congestive heart failure complicating valvular regurgitation which is an indication for urgent valvular replacement, uncontrollable infection, dehiscence in a...

  • Combined Retrograde/Antegrade Approach to Transcatheter Closure of an Aortic Paravalvular Leak. Damluji, Abdulla A.; Kaynak, Husnu E.; Heldman, Alan W. // Texas Heart Institute Journal;Oct2015, Vol. 42 Issue 5, p443 

    New interventional techniques have made transcatheter closure of aortic paravalvular leaks a viable therapeutic option to treat the sequelae of these defects, including congestive heart failure and hemolysis. We report the transcatheter closure of an aortic paravalvular leak via a combined...

  • Successful Aortic Root Replacement with Aortic Arch Aneurysm Repair: A Case Report. Withurawanit, Wichaya; Samankatiwat, Piya; Khajarern, Siam // Thai Journal of Surgery;Apr-Jun2007, Vol. 28 Issue 2, p69 

    We report a successful first stage repair in a patient with extensive aortic aneurysm. A 61 year-old woman with hypertension for 4 years came to the hospital with problems of congestive heart failure. Physical examination and investigations revealed severe aortic regurgitation with compromised...

  • The Heart in Heart Failure. Weisller, Arnold M. // Annals of Internal Medicine;Nov68, Vol. 69 Issue 5, p929 

    Focuses on the possible defect in the intrinsic contractile performance of the myocardium in the occurrence of congestive heart failure. Description of the normal myocardium; Structural basis for cardiac contraction; Myocardial contraction in heart failure.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics