Evaluation of two novel aluminum-free, zinc-based glass polyalkenoate cements as alternatives to PMMA bone cement for use in vertebroplasty and balloon kyphoplasty

Lewis, Gladius; Towler, Mark R.; Boyd, Daniel; German, Matthew J.; Wren, Anthony W.; Clarkin, Owen M.; Yates, Andrew
January 2010
Journal of Materials Science: Materials in Medicine;Jan2010, Vol. 21 Issue 1, p59
Academic Journal
Vertebroplasty (VP) and balloon kyphoplasty (BKP) are now widely used for treating patients in whom the pain due to vertebral compression fractures is severe and has proved to be refractory to conservative treatment. These procedures involve percutaneous delivery of a bolus of an injectable bone cement either directly to the fractured vertebral body, VB (VP) or to a void created in it by an inflatable bone tamp (BKP). Thus, the cement is a vital component of both procedures. In the vast majority of VPs and BKPs, a poly(methyl methacrylate) (PMMA) bone cement is used. This material has many shortcomings, notably lack of bioactivity and very limited resorbability. Thus, there is room for alternative cements. We report here on two variants of a novel, bioactive, Al-free, Zn-based glass polyalkenoate cement (Zn-GPC), and how their properties compare to those of an injectable PMMA bone cement (SIMPL) that is widely used in VP and BKP. The properties determined were injectability, radiopacity, uniaxial compressive strength, and biaxial flexural modulus. In addition, we compared the compression fatigue lives of a validated synthetic osteoporotic VB model (a polyurethane foam cube with an 8 mm-diameter through-thickness cylindrical hole), at 0–2300 N and 3 Hz, when the hole was filled with each of the three cements. A critical review of the results suggests that the performance of each of the Zn-GPCs is comparable to that of SIMPL; thus, the former cements merit further study with a view to being alternatives to an injectable PMMA cement for use in VP and BKP.


Related Articles

  • Vertebroplasty and kyphoplasty. Suresh, Sri Priya; Whitehouse, Richard W. // Journal of the British Menopause Society;2005, Vol. 11 Issue 1, p28 

    Vertebral compression fractures are common in elderly populations and in particular in postmenopausal women as a consequence of osteoporosis. Percutaneous vertebroplasty and kyphoplasty are minimally invasive procedures that are increasingly used to treat persistent or severe acute pain from...

  • Some failure modes of four clinical bone cements. Liu, C; Green, S M; Watkins, N D; Gregg, P J; McCaskie, A W // Proceedings of the Institution of Mechanical Engineers -- Part H;Jul2001, Vol. 215 Issue 4, p359 

    The fracture or failure behaviours of four commercial acrylic-based bone cements have been examined in tensile, bending and compression modes, and their mechanical properties are reviewed. It was found that Palacos R-40 bone cement had high radiopaque agent concentration, with high surface...

  • Flow characteristics of curing polymethyl methacrylate bone cement. Dunne, N J; Orr, J F // Proceedings of the Institution of Mechanical Engineers -- Part H;Jul98, Vol. 212 Issue 3, p199 

    During polymerization, polymethyl methacrylate bone cements have complex viscoelastic characteristics. Within a short working time they transform from dough-like consistencies to solid cements. Therefore, the time at which a cement is introduced to cancellous bone surfaces and subjected to...

  • Pullout strength of pedicle screws with cement augmentation in severe osteoporosis: A comparative study between cannulated screws with cement injection and solid screws with cement pre-filling. Lih-Huei Chen; Ching-Lung Tai; De-Mei Lee; Po-Liang Lai; Yen-Chen Lee; Chi-Chien Niu; Wen-Jer Chen // BMC Musculoskeletal Disorders;2011, Vol. 12 Issue 1, p33 

    Background: Pedicle screws with PMMA cement augmentation have been shown to significantly improve the fixation strength in a severely osteoporotic spine. However, the efficacy of screw fixation for different cement augmentation techniques, namely solid screws with retrograde cement pre-filling...

  • Intraprocedural Adjacent Level Compression Fracture During Vertebroplasty Secondary to Cement Leakage into the Disc Space. Sprague, Robert R.; Berkmen, Turgut // Current Medical Imaging Reviews;2008, Vol. 4 Issue 3, p181 

    An elderly female underwent three level vertebroplasty for painful compression fractures of the thoracolumbar junction. During injection of the third level, she developed severe pain resulting from an acute adjacent level fracture secondary to substantial cement leakage into the disc space. This...

  • An innovative multi-component variate that reveals hierarchy and evolution of structural damage in a solid: application to acrylic bone cement. Qi, Gang; Fan, Ming; Lewis, Gladius; Wayne, Steven // Journal of Materials Science: Materials in Medicine;Feb2012, Vol. 23 Issue 2, p217 

    A major limitation of solid mechanics is the inability to take into account the influence of hierarchy and evolution of the inherent microscopic structure on evaluating the performance of materials. Irreversible damage and fracture in solids, studied commonly as cracks, flaws, and conventional...

  • Medtronic Launches Quick-to-Dough Bone Cement in the US.  // Biomedical Market Newsletter;5/17/2011, p653 

    The article offers brief information on Kyphon Xpede Bone Cement from Medtronic Inc.

  • Using Displacement Sensor to Determinate the Fracture Toughness of PMMA Bone Cement. Yongzhi Xu; Youzhi Wang; Guozhi Tian // Sensors & Transducers (1726-5479);May2013, Vol. 152 Issue 5, p27 

    Polymethylmethacrylate-based (PMMA) bone cements incorporating multiwalled carbon nanotubes (MWCNTs) as a means of reinforcement were prepared, and their structure and properties were investigated by displacement sensor and chevron-notched test method. The aim of this study was to determine the...

  • A Particle Model for Prediction of Cement Infiltration of Cancellous Bone in Osteoporotic Bone Augmentation. Basafa, Ehsan; Murphy, Ryan J.; Kutzer, Michael D.; Otake, Yoshito; Armand, Mehran // PLoS ONE;Jun2013, Vol. 8 Issue 6, p1 

    Femoroplasty is a potential preventive treatment for osteoporotic hip fractures. It involves augmenting mechanical properties of the femur by injecting Polymethylmethacrylate (PMMA) bone cement. To reduce the risks involved and maximize the outcome, however, the procedure needs to be carefully...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics