The mesoporosity of microparticles spray dried from trehalose and nanoparticle hydroxyapatite depends on the ratio of nanoparticles to sugar and nanoparticle surface charge

Wright, David M.; Saracevic, Zlatko S.; Kyle, Nigel H.; Motskin, Michael; Skepper, Jeremy N.
January 2010
Journal of Materials Science: Materials in Medicine;Jan2010, Vol. 21 Issue 1, p189
Academic Journal
The ratio of hydroxyapatite (HA) nanoparticles (NP) to trehalose in composite microparticle (MP) vaccine vehicles by determining inter-nanoparticle space potentially influences antigen release. Mercury porosimetry and gas adsorption analysis have been used quantify this space. Larger pores are present in MPs spray dried solely from nanoparticle gel compared with MPs spray dried from nanoparticle colloid which have less inter-nanoparticle volume. This is attributed to tighter nanoparticle packing caused by citrate modification of their surface charge. The pore size distributions (PSD) for MP where the trehalose has been eliminated by combustion generally broaden and shifts to higher values with increasing initial trehalose content. Modal pore size, for gel derived MPs is comparable to modal NP width below 30% initial trehalose content and approximates to modal NP length (~50 nm) at 60% initial trehalose content. For colloidally derived MPs this never exceeds the modal NP width. Pore-sizes are comparable, to surface inter-nanoparticle spacings observed by SEM.


Related Articles

  • Smart Magnetically Responsive Hydrogel Nanoparticles Prepared by a Novel Aerosol-Assisted Method for Biomedical and Drug Delivery Applications. El-Sherbiny, Ibrahim M.; Smyth, Hugh D. C. // Journal of Nanomaterials;2011, p1 

    We have developed a novel spray gelation-based method to synthesize a new series of magnetically responsive hydrogel nanoparticles for biomedical and drug delivery applications. The method is based on the production of hydrogel nanoparticles from sprayed polymeric microdroplets obtained by an...

  • Properties of Nanostructured Hydroxyapatite Prepared by a Spray Drying Technique. Chow, Laurence C.; Sun, Limin; Hockey, Bernard // Journal of Research of the National Institute of Standards & Tec;Nov/Dec2004, Vol. 109 Issue 6, p543 

    In previous studies nano sized hydroxyapatite (HA) particles were prepared by solgel or precipitation methods, in which the products were washed by aqueous or non-aqueous liquids to remove impurities or undesired components. The washing is know to modify the surfaces of the cystalline particles....

  • Structure of Biocompatible Coatings Produced from Hydroxyapatite Nanoparticles by Detonation Spraying. Nosenko, Valentyna; Strutynska, Nataliia; Vorona, Igor; Zatovsky, Igor; Dzhagan, Volodymyr; Lemishko, Sergiy; Epple, Matthias; Prymak, Oleg; Baran, Nikolai; Ishchenko, Stanislav; Slobodyanik, Nikolai; Prylutskyy, Yuriy; Klyui, Nickolai; Temchenko, Volodymyr // Nanoscale Research Letters;12/2/2015, Vol. 10 Issue 1, p1 

    Detonation-produced hydroxyapatite coatings were studied by scanning electron microscopy (SEM), X-ray powder diffraction (XRD), Raman spectroscopy, and electron paramagnetic resonance (EPR) spectroscopy. The source material for detonation spraying was a B-type carbonated hydroxyapatite powder....

  • Numerical simulation of spray drying of hydroxyapatite nanoparticles. Julklang, Wittaya; Golman, Boris // Clean Technologies & Environmental Policy;Jun2015, Vol. 17 Issue 5, p1217 

    As a way of improving handling safety of nanoparticles for environmental applications on an industrial scale, we considered the consolidation of nanoparticles into micron-sized spray-dried agglomerates. Spray drying has recently been favored for manufacturing of nanoparticle agglomerates...

  • Putative Nanobacteria Represent Physiological Remnants and Culture By-Products of Normal Calcium Homeostasis. Young, John D.; Martel, Jan; Young, Lena; Cheng-Yeu Wu; Young, Andrew; Young, David // PLoS ONE;2009, Vol. 4 Issue 2, p1 

    Putative living entities called nanobacteria (NB) are unusual for their small sizes (50-500 nm), pleomorphic nature, and accumulation of hydroxyapatite (HAP), and have been implicated in numerous diseases involving extraskeletal calcification. By adding precipitating ions to cell culture medium...

  • Hydroxyapatite nanoparticles modified by peroxide groups. Gordeev, S.; Nikol'skii, A.; Osmolovskaya, O.; Osmolovskii, M. // Russian Journal of General Chemistry;Apr2014, Vol. 84 Issue 4, p789 

    A letter to the editor is presented related to modification of hydroxyapatite nanoparticles using peroxides.

  • LiFAP-based PVdF–HFP microporous membranes by phase-inversion technique with Li/LiFePO4 cell. Aravindan, V.; Vickraman, P.; Sivashanmugam, A.; Thirunakaran, R.; Gopukumar, S. // Applied Physics A: Materials Science & Processing;Dec2009, Vol. 97 Issue 4, p811 

    Polyvinylidenefluoride–hexafluoropropylene-based (PVdF–HFP-based) gel and composite microporous membranes (GPMs and CPMs) were prepared by phase-inversion technique in the presence 10 wt% of AlO(OH) n nanoparticles. The prepared membranes were gelled with 0.5-M LiPF3(CF2CF3)3...

  • Preparation and characterization of magnetic TiO2/ZnFe2O4 photocatalysts by a sol–gel method. Baoping Zhang; Jinlong Zhang; Feng Chen // Research on Chemical Intermediates;2008, Vol. 34 Issue 4, p375 

    A magnetic TiO2/ZnFe2O4 photocatalyst was prepared by a sol–gel method, and X-ray diffraction (XRD), magnetic and photocatalytic properties analysis were employed to characterize this photocatalyst. The XRD results show that ZnFe2O4 can prevent the transformation of titania from anatase...

  • Numerical Modelling of Gelating Aerosols. Babovsky, Hans // AIP Conference Proceedings;9/15/2008, Vol. 1048 Issue 1, p913 

    The numerical simulation of the gel phase transition of an aerosol system is an interesting and demanding task. Here, we follow an approach first discussed in [6, 8] which turns out as a useful numerical tool. We investigate several improvements and generalizations. In the center of interest are...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics