TITLE

Assessment of sex-specific effects in a genome-wide association study of rheumatoid arthritis

AUTHOR(S)
Zhuang, Joanna J.; Morris, Andrew P.
PUB. DATE
January 2009
SOURCE
BMC Proceedings;2009 Supplement 7, Vol. 3, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Rheumatoid arthritis (RA) is three times more common in females than in males, suggesting that sex may play a role in modifying genetic associations with disease. We have addressed this hypothesis by performing sex-differentiated and sex-interaction analyses of a genome-wide association study of RA in a North American population. Our results identify a number of novel associations that demonstrate strong evidence of association in both sexes combined, with no evidence of heterogeneity in risk between males and females. However, our analyses also highlight a number of associations with RA in males or females only. These signals may represent true sex-specific effects, or may reflect a lack of power to detect association in the smaller sample of males, and thus warrant further investigation.
ACCESSION #
47480671

 

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