TITLE

Plaque type and composition as evaluated non-invasively by MSCT angiography and invasively by VH IVUS in relation to the degree of stenosis

PUB. DATE
December 2009
SOURCE
Heart;Dec2009, Vol. 95 Issue 24, p7
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Imaging of coronary plaques has traditionally focused on evaluating degree of stenosis, as the risk for adverse cardiac events increases with stenosis severity. However, the relation between plaque composition and severity of stenosis remains largely unknown. Objective: To assess plaque composition (non-invasively by multislice computed tomography (MSCT) angiography and invasively by virtual histology intravascular ultrasound (VH IVUS)) in relation to degree of stenosis. Methods: 78 patients underwent MSCT (identifying three plaque types; non-calcified, calcified, mixed) followed by invasive coronary angiography and VH IVUS. VH IVUS evaluated plaque burden, minimal lumen area and plaque composition (fibrotic, fibro-fatty, necrotic core, dense calcium) and plaques were classified as fibrocalcific, fibroatheroma, thin-capped fibroatheroma (TCFA), pathological intimal thickening. For each plaque, percentage stenosis was evaluated by quantitative coronary angiography. Significant stenosis was defined >50% stenosis. Results: Overall, 43 plaques (19%) corresponded to significant stenosis. Of the 227 plaques analysed, 70 were non-calcified plaques (31%), 96 mixed (42%) and 61 calcified (27%) on MSCT. Plaque types on MSCT were equally distributed among significant and non-significant stenoses. VH IVUS identified that plaques with significant stenosis had higher plaque burden (67% (11%) vs 53% (12%), p<0.05) and smaller minimal lumen area (4.6 (3.8-6.8) mm² vs 7.3 (5.4-10.5) mm², p<0.05). Interestingly, no differences were observed in percentage fibrotic, fibro-fatty, necrotic core and dense calcium. Non-significant stenoses were more frequently classified as pathological intimal thickening (46 (25%) vs 3 (7%), p<0.05), although TCFA (more vulnerable plaque) was distributed equally (p?=?0.18). Conclusion: No evident association exists between the degree of stenosis and plaque composition or vulnerability, as evaluated non-invasively by MSCT and invasively by VH IVUS.
ACCESSION #
47477733

 

Related Articles

  • Radiation dose in helical CT for detection of pulmonary embolism. Diederich, S. // European Radiology;Jul2003, Vol. 13 Issue 7, p1491 

    Focuses on the radiation exposure of helical computed tomography (CT) for detection of pulmonary embolism compared with pulmonary angiography. Usefulness of CT for the diagnosis of pulmonary emboli by direct demonstration of emboli within the pulmonary arteries; Demonstration by initial scan...

  • Low-dose, 128-slice, dual-source CT coronary angiography: accuracy and radiation dose of the high-pitch and the step-and-shoot mode. Alkadhi, Hatem; Stolzmann, Paul; Desbiolles, Lotus; Baumueller, Stephan; Goetti, Robert; Plass, Andre; Scheffel, Hans; Feuchtner, Gudrun; Falk, Volkmar; Marincek, Borut; Leschka, Sebastian // Heart;Jun2010, Vol. 96 Issue 12, p933 

    Objective To compare the diagnostic accuracy and radiation doses of two low-dose protocols for coronary artery imaging with second-generation, dual-source CT in comparison with catheter angiography (CA). Design, setting and patients Prospective, single-centre study conducted in a referral centre...

  • The Role of Computer-Aided 3-Dimensional Analytic Tools and Virtual Microscopy in the Investigation of Radiologic-Pathologic Correlation. Furuya, Keizo; Maeda, Toshiharu; Nakanura, Seiji; Kikuchi, Takanori // Archives of Pathology & Laboratory Medicine;Jun2009, Vol. 133 Issue 6, p912 

    To cope with recent advances in radiologic imaging technology, a corresponding method for pathomorphologic demonstration should be developed to promote better understanding of radiologic-pathologic correlation. We attempted to obtain gross and microscopic images by using a 3-dimensional analytic...

  • Analysis of coronary angiography related psychophysiological responses.  // BioMedical Engineering OnLine;2011, Vol. 10 Issue 1, p71 

    The article presents a study which analyzes psychophysiological responses induced by the coronary angiography, used for diagnosis of cardiovascular disease, instead of subjective methods such as a questionnaire. It also examines the effect of the tranquilizer on the psychophysiological...

  • TAKAYASU'S DISEASE. Tardif, Luc; Mignault, Jean De L.; Derome, Leon; Roy, Paul // Angiology;Sep1965, Vol. 16 Issue 9, p538 

    This case study is presented mainly in order to illustrate the decisive information acquired through angiography in the diagnosis of Takayasu's disease, a condition which remains relatively rare. Only a few demonstrative pictures have been published in reports on the existence, site and extent...

  • Steroid-responsive sterile inflammation after transradial cardiac catheterisation using a sheath with hydrophilic coating. Lim, J.; Suri, A.; Chua, T. P. // Heart;Jul2009, Vol. 95 Issue 14, p1202 

    The article describes the case of a 64-year-old woman who underwent coronary angiography. The authors mention that she found an erythematous and tender swelling at the right radial artery access site fifteen days after the angiography. They also state that a 7-day course of flucloxacillin that...

  • Feasibility of 320-row area detector CT coronary angiography using 40 mL of contrast material: assessment of image quality and diagnostic accuracy. Kim, Rihyeon; Park, Eun-Ah; Lee, Whal; Chung, Jin; Chung, Jin Wook // European Radiology;Nov2016, Vol. 26 Issue 11, p3802 

    Objectives: To assess the image quality and diagnostic accuracy of 320-row area detector CT (320-ADCT) coronary angiography using 40 mL of contrast material in comparison with 60-mL protocol.Methods: This retrospective study included 183 patients who underwent...

  • Characterization of hepatocellular carcinomas with triphasic CT and correlation with histopathologic findings. Karahan, O.I.; Yikilmaz, A.; Isin, S.; Orhan, S. // Acta Radiologica;Nov2003, Vol. 44 Issue 6, p566 

    Purpose: To determine the utility of triphasic CT in the characterization of hepatocellular carcinomas (HCCs) and correlations with histopathologic findings. Material and Methods: Thirty patients with hepatocellular carcinomas were included in the study and triphasic CT...

  • Histopathological characterization of hepatocellular carcinomas which are undetected by dynamic computed tomography. Yamamoto, Takatsugu; Hirohashi, Kazuhiro; Sakabe, Katsu; Shuto, Taichi; Uenishi, Takahiro; Ogawa, Masao; Tanaka, Shogo; Tanaka, Hiromu; Kubo, Shoji; Kaneda, Kenji; Sakurai, Masami // Comparative Hepatology;2004 Supplement 1, Vol. 3, pS56 

    A conference paper that investigates histopathological features of hepatocellular carcinomas (HCCs) not detected by dynamic computed tomography (CT) is presented. Results reveal that HCCs undetectable in dynamic CT were typically well differentiated HCCs with intratumoral Glisson's sheath, no...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics