Effects of human midkine on spontaneous resorption of herniated intervertebral discs

Guoshun Zhou; Licheng Dai; Xuesheng Jiang; Zhihong Ma; Jinliang Ping; Jianyou Li; Xiongfeng Li
January 2010
International Orthopaedics;Jan2010, Vol. 34 Issue 1, p103
Academic Journal
Abstract  This study was performed in 36 rabbits to investigate the role of midkine (MK) in the resorption of herniated intervertebral discs. The L1-2 disc was excised and immersed in one of three kinds of solution for two hours before relocation into the L4 epidural space. In the MK-treated group, the weight of relocated intervertebral discs decreased more over time than in the control group. Newly formed vessels and inflammatory cells were more frequently observed in the MK-treated group than in the control group two weeks after surgery. The degradation of matrix was more significant in the MK-treated group than in the control group four weeks after surgery. Larger areas were replaced by fibrous tissues in the MK-treated group eight weeks after surgery. Thus, MK can accelerate the resorption of the intervertebral disc relocation to the epidural space. Epidural injection of MK may contribute to the therapy of lumber disc herniation.


Related Articles

  • Higher preoperative Oswestry Disability Index is associated with better surgical outcome in upper lumbar disc herniations. Saberi, Hooshang; Isfahani, Arash Vatankhahan // European Spine Journal;Jan2008, Vol. 17 Issue 1, p117 

    To evaluate the surgical outcome in terms of functional and subjective recovery, patients who needed discectomies at L1–L2, L2–L3 and L3–L4 levels were compared with an age and sex-matched group of patients who required L4–L5 and L5–S1 discectomies. We...

  • Reassessment of Automated Percutaneous Lumbar Diskectomy for Herniated Disks.  // JAMA: Journal of the American Medical Association;4/24/91, Vol. 265 Issue 16, p2122 

    Discusses the use of automated percutaneous lumbar diskectomy for the treatment of protruding lumbar disk. Information on back pains associated with herniated lumbar disks; Advantages and disadvantages of lumbar diskectomy; Results of studies on the effectiveness of the surgical procedure.

  • Quicker fix for backs.  // Body Bulletin;Nov98, p3 

    Provides information on microsurgery. Advantage of using the procedure in repairing a herniated disk; Success rate of microdiskectomy.

  • Laminectomy Compared with Laparoscopic Diskectomy and Outpatient Laparoscopic Diskectomy for Herniated L5-S1 Intervertebral Disk. Slotman, Gus J.; Stein, Sherman C. // Journal of Laparoendoscopic & Advanced Surgical Techniques;Oct98, Vol. 8 Issue 5, p261 

    Deals with a study which evaluated the clinical efficacy and cost effectiveness of inpatient and outpatient laparoscopic lumbar diskectomy (LLD). Comparison with laminectomy in the surgical treatment of disabling L5-S1 disk herniation; Morbidity after LLD included transient unrinary retention...

  • A quick fix for big back problems. Marion, Matt // Men's Health;Oct98, Vol. 13 Issue 8, p38 

    Provides an overview of a surgical procedure for repairing herniated disks. Details on the microsurgical procedure; Success rate of the procedure.

  • Lumbar Disc Herniation Combined with Posterior Apophyseal Ring Separation in a Young Child: A Case Report. Pius Kim; Seok Won Kim; Chang Il Ju; Hyeun Sung Kim // Korean Journal of Spine;Sep2015, Vol. 12 Issue 3, p143 

    Lumbar disc herniation in children aged 10 years or less is extremely uncommon and posterior apophyseal ring separation is not a common injury that usually occurs in adolescents or young adults after a sports-related microtraumatism. The authors report an unique case of 10-year-old boy who...

  • LUMBER DISCITIS; PREVALENCE AND MANAGEMENT AFTER LUMBER DISC SURGERY. Ahmad, Mumtaz; Yasin, Muhammad // Professional Medical Journal;Oct2010, Vol. 17 Issue 4, p628 

    Objectives: To study the occurrence of discitis after lumber disc surgery and its management. Study Design: Observational study. Setting: Department of Neurosurgery QAMC/ BVH Bahawalpur. Period: April 2006 to May 2009. Patients and Methods: This study includes 400 patients who underwent standard...

  • Reoperation after lumbar disc surgery in two hundred and seven patients. Cheng, Jiwei; Wang, Hongwei; Zheng, Wenjie; Li, Changqing; Wang, Jian; Zhang, Zhengfeng; Huang, Bo; Zhou, Yue // International Orthopaedics;Aug2013, Vol. 37 Issue 8, p1511 

    Purpose: The purpose of this study was to compare the causes and characteristics of reoperations after different primary operations for lumbar disc herniation (LDH). Methods: Out of a series of 5,280 patients who underwent operations for LDH between 2001 and 2012, 207 patients (135 male and 72...

  • A Novel Approach to the Surgical Treatment of Lumbar Disc Herniations: Indications of Simple Discectomy and Posterior Transpedicular Dynamic Stabilization Based on Carragee Classification. Ozer, A. F.; Keskin, F.; Oktenoglu, T.; Suzer, T.; Ataker, Y.; Gomleksiz, C.; Sasani, M. // Advances in Orthopedics;2013, p1 

    Surgery of lumbar disc herniation is still a problem since Mixter and Barr. Main trouble is dissatisfaction after the operation. Today there is a debate on surgical or conservative treatment despite spending great effort to provide patients with satisfaction. The main problem is segmental...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics