TITLE

Immunohistochemical study of angiogenesis after local administration of platelet-rich plasma in a patellar tendon defect

AUTHOR(S)
Dimitris Lyras; Kostas Kazakos; Dionysios Verettas; Alexandros Polychronidis; Constantinos Simopoulos; Sotirios Botaitis; George Agrogiannis; Anna Kokka; Efstratios Patsouris
PUB. DATE
January 2010
SOURCE
International Orthopaedics;Jan2010, Vol. 34 Issue 1, p143
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  A full thickness defect was made in the central portion of the patellar tendon of 48 New Zealand white rabbits. Platelet-rich plasma (PRP) gel was then applied and filled the tendon defect. The same procedure was performed in the control group, without the application of PRP. Animals were sacrificed after one, two, three, and four weeks. Histological and immunohistochemical analyses using a monoclonal antibody against CD31 were performed. The histological examination showed a superior healing process in the PRP group compared with the control group. Especially in the third week, the tissue formed in the PRP group was more mature and dense with less elastic fibres remaining. Neovascularisation was significantly higher in the PRP group during the first two weeks and significantly lower in the third and fourth weeks (p 
ACCESSION #
47380013

 

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