TITLE

Reconciling conflicting clinical studies of antioxidant supplementation as HIV therapy: a mathematical approach

AUTHOR(S)
van Gaalen, Rolina D.; Wahl, Lindi M.
PUB. DATE
January 2009
SOURCE
BMC Public Health;2009 Supplement 1, Vol. 9, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Small, highly reactive molecules called reactive oxygen species (ROS) play a crucial role in cell signalling and infection control. However, high levels of ROS can cause significant damage to cell structure and function. Studies have shown that infection with the human immunodeficiency virus (HIV) results in increased ROS concentrations, which can in turn lead to faster progression of HIV infection, and cause CD4+ T-cell apoptosis. To counteract these effects, clinical studies have explored the possibility of raising antioxidant levels, with mixed results. Methods: In this paper, a mathematical model is used to explore this potential therapy, both analytically and numerically. For the numerical work, we use clinical data from both HIV-negative and HIV-positive injection drug users (IDUs) to estimate model parameters; these groups have lower baseline concentrations of antioxidants than non-IDU controls. Results: Our model suggests that increases in CD4+ T cell concentrations can result from moderate levels of daily antioxidant supplementation, while excessive supplementation has the potential to cause periods of immunosuppression. Conclusion: We discuss implications for HIV therapy in IDUs and other populations which may have low baseline concentrations of antioxidants.
ACCESSION #
47370868

 

Related Articles

  • Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training. Gounder, Sellamuthu S.; Kannan, Sankaranarayanan; Devadoss, Dinesh; Miller, Corey J.; Whitehead, Kevin S.; Odelberg, Shannon J.; Firpo, Matthew A.; Paine III, Robert; Hoidal, John R.; Abel, E. Dale; Rajasekaran, Namakkal S.; Huang, Yu // PLoS ONE;Sep2012, Vol. 7 Issue 9, Special section p1 

    Aging promotes accumulation of reactive oxygen/nitrogen species (ROS/RNS) in cardiomyocytes, which leads to contractile dysfunction and cardiac abnormalities. These changes may contribute to increased cardiovascular disease in the elderly. Inducible antioxidant pathways are regulated by nuclear...

  • Oxidative Stress-Induced DNA Damage and Apoptosis in Clove Buds-Treated MCF-7 Cells. Kello, Martin; Takac, Peter; Kubatka, Peter; Kuruc, Tomas; Petrova, Klaudia; Mojzis, Jan // Biomolecules (2218-273X);Jan2020, Vol. 10 Issue 1, preceding p1 

    In recent decades, several spices have been studied for their potential in the prevention and treatment of cancer. It is documented that spices have antioxidant, anti-inflammatory, immunomodulatory, and anticancer effects. Themainmechanisms of spices action included apoptosis induction,...

  • HIV-1 Nef increases astrocyte sensitivity towards exogenous hydrogen peroxide. Masanetz, Sabine; Lehmann, Michael H. // Virology Journal;2011, Vol. 8 Issue 1, p35 

    Background: HIV-1 infected individuals are under chronic exposure to reactive oxygen species (ROS) considered to be instrumental in the progression of AIDS and the development of HIV-1 associated dementia (HAD). Astrocytes support neuronal function and protect them against cytotoxic substances...

  • Neuroprotective effects of Withania coagulans root extract on CA1 hippocampus following cerebral ischemia in rats. Sarbishegi, Maryam; Heidari, Zahra; Sagheb, Hamidreza Mahmoudzadeh; Valizadeh, Moharram; Doostkami, Mahboobeh // Avicenna Journal of Phytomedicine;Jun2016, Vol. 6 Issue 4, p399 

    Objective: Oxygen free radicals may be implicated in the pathogenesis of ischemia reperfusion damage. The beneficial effects of antioxidant nutrients, as well as complex plant extracts, on cerebral ischemia-reperfusion injuries are well known. This study was conducted to determine the effects of...

  • Efficacy of Low Temperature Plasma against SCaBER Cancer Cells. Mohades, Soheila; Barekzi, Nazir; Laroussi, Mounir // Plasma Processes & Polymers;Dec2014, Vol. 11 Issue 12, p1150 

    The efficacy of the plasma pencil is studied for its cancer therapeutics effects against the SCaBER cell line. First, the SCaBER cells in media were treated with different exposure times of low temperature plasma (LTP). Secondly, LTP activated media was generated by treating the media prior to...

  • NAC, Tiron and Trolox Impair Survival of Cell Cultures Containing Glioblastoma Tumorigenic Initiating Cells by Inhibition of Cell Cycle Progression. Monticone, Massimiliano; Taherian, Razieh; Stigliani, Sara; Carra, Elisa; Monteghirfo, Stefano; Longo, Luca; Daga, Antonio; Dono, Mariella; Zupo, Simona; Giaretti, Walter; Castagnola, Patrizio // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    Reactive oxygen species (ROS) are metabolism by-products that may act as signaling molecules to sustain tumor growth. Antioxidants have been used to impair cancer cell survival. Our goal was to determine the mechanisms involved in the response to antioxidants of a human cell culture (PT4)...

  • Antioxidants Maintain E-Cadherin Levels to Limit Drosophila Prohemocyte Differentiation. Gao, Hongjuan; Wu, Xiaorong; Simon, LaTonya; Fossett, Nancy // PLoS ONE;Sep2014, Vol. 9 Issue 9, p1 

    Mitochondrial reactive oxygen species (ROS) regulate a variety of biological processes by networking with signal transduction pathways to maintain homeostasis and support adaptation to stress. In this capacity, ROS have been shown to promote the differentiation of progenitor cells, including...

  • Tempol, an Intracellular Antioxidant, Inhibits Tissue Factor Expression, Attenuates Dendritic Cell Function, and Is Partially Protective in a Murine Model of Cerebral Malaria. Francischetti, Ivo M. B.; Gordon, Emile; Bizzarro, Bruna; Gera, Nidhi; Andrade, Bruno B.; Oliveira, Fabiano; Ma, Dongying; Assumpção, Teresa C. F.; Ribeiro, José M. C.; Pena, Mirna; Qi, Chen-Feng; Diouf, Ababacar; Moretz, Samuel E.; Long, Carole A.; Ackerman, Hans C.; Pierce, Susan K.; Sá-Nunes, Anderson; Waisberg, Michael // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    Background: The role of intracellular radical oxygen species (ROS) in pathogenesis of cerebral malaria (CM) remains incompletely understood. Methods and Findings: We undertook testing Tempol—a superoxide dismutase (SOD) mimetic and pleiotropic intracellular antioxidant—in cells...

  • Antioxidant Activity of Inulin and Its Role in the Prevention of Human Colonic Muscle Cell Impairment Induced by Lipopolysaccharide Mucosal Exposure. Pasqualetti, Valentina; Altomare, Annamaria; Guarino, Michele Pier Luca; Locato, Vittoria; Cocca, Silvia; Cimini, Sara; Palma, Rossella; Alloni, Rossana; De Gara, Laura; Cicala, Michele // PLoS ONE;May2014, Vol. 9 Issue 5, p1 

    Background: Fructans, such as inulin, are dietary fibers which stimulate gastro-intestinal (GI) function acting as prebiotics. Lipopolysaccharide (LPS) impairs GI motility, through production of reactive oxygen species. The antioxidant activity of various fructans was tested and the protective...

  • Anti-Cancer Therapies of 21st Century: Novel Approach to Treat Human Cancers Using Cold Atmospheric Plasma. Ratovitski, Edward A.; Cheng, Xiaoqian; Yan, Dayun; Sherman, Jonathan H.; Canady, Jerome; Trink, Barry; Keidar, Michael // Plasma Processes & Polymers;Dec2014, Vol. 11 Issue 12, p1128 

    Cold atmospheric plasma (CAP) has just recently been showing promising anti-cancer activities supported by ability to induce cell death via apoptosis and cell cycle arrest leading to tumor cell destruction in vitro, and in vivo. Several studies showed the ability of CAP-activated media to...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics