TITLE

Oral Absorption and the Biopharmaceutics Classification System

AUTHOR(S)
Deliang Zhou; Yihong Qiu
PUB. DATE
November 2009
SOURCE
Journal of Validation Technology;Autumn2009, Vol. 15 Issue 4, p62
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article summarizes the factors affecting oral drug absorption and discusses the concept and applications of biopharmaceutics classification system (BCS). The small intestine is the major site of drug molecule absorption in the gastrointestinal tract. The drug molecules are required to pass through the epithelium and the walls of the blood or lymph capillaries. Physiological processes that may affect the dissolution and absorption of a drug include secretion, digestion and absorption. Another factor that impact absorption is the pH, which changes along the gastrointestinal tracts. The role of dosage form in achieving the desired oral absorption of a drug is explained, as well as the impact of chemical degradations on oral bioavailability.
ACCESSION #
47337026

 

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