TITLE

Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components

AUTHOR(S)
Han-Lin Gong; Wen-Fu Tang; Qin Yu; Jin Xiang; Qing Xia; Guang-Yuan Chen; Xi Huang; Mao-Zhi Liang; Geng-Tao Liu
PUB. DATE
December 2009
SOURCE
World Journal of Gastroenterology;12/21/2009, Vol. 15 Issue 47, p5992
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
AIM: To investigate the effect of severe acute pancreatitis (SAP) on pharmacokinetics of Da-Cheng-Qi Decoction (DCQD) components in rats. METHODS: Rats were divided into SAP group and sham-operation group as a control group (n = 6). Rhein, chrysophanol, rheochrysidin, magnolol, hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics. RESULTS: Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by gavage. The Cmax (chrysophanol, P = 0.0059; rheochrysidin, P = 0.0288; magnolol, P = 0.0487; hesperidin, P = 0.0277; naringin, P = 0.0023) and AUC (rhein, P = 0.0186; chrysophanol, P = 0.0013; magnolol, P = 0.001; hesperidin, P = 0.0081; naringin, P = 0.0272) of DCQD component were obviously lower in SAP group than in control group. The T1/2α of chrysophanol and rheochrysidin (P = 0.0467 and 0.0005, respectively) and Tmax of chrysophanol and rheochrysidin (P = 0.0101 and 0.0037, respectively) lasted longer in SAP group than in control group. CONCLUSION: SAP can significantly impact the absorption of components in rats and their pharmacokinetic parameters.
ACCESSION #
47336376

 

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