TITLE

Protocol: Transmission and prevention of influenza in Hutterites: Zoonotic transmission of influenza A: swine & swine workers

AUTHOR(S)
Russell, Margaret L.; Keenliside, Julia; Webby, Richard; Fonseca, Kevin; Singh, Pam; Moss, Lorraine; Loeb, Mark
PUB. DATE
January 2009
SOURCE
BMC Public Health;2009, Vol. 9, p420
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Among swine, reassortment of influenza virus genes from birds, pigs, and humans could generate influenza viruses with pandemic potential. Humans with acute infection might also be a source of infection for swine production units. This article describes the study design and methods being used to assess influenza A transmission between swine workers and pigs. We hypothesize that transmission of swine influenza viruses to humans, transmission of human influenza viruses to swine, and reassortment of human and swine influenza A viruses is occurring. The project is part of a Team Grant; all Team Grant studies include active surveillance for influenza among Hutterite swine farmers in Alberta, Canada. This project also includes non- Hutterite swine farms that are experiencing swine respiratory illness. Methods/Design: Nurses conduct active surveillance for influenza-like-illness (ILI), visiting participating communally owned and operated Hutterite swine farms twice weekly. Nasopharyngeal swabs and acute and convalescent sera are obtained from persons with any two such symptoms. Swabs are tested for influenza A and B by a real time RT-PCR (reverse transcriptase polymerase chain reaction) at the Alberta Provincial Laboratory for Public Health (ProvLab). Test-positive participants are advised that they have influenza. The occurrence of test-positive swine workers triggers sampling (swabbing, acute and convalescent serology) of the swine herd by veterinarians. Specimens obtained from swine are couriered to St. Jude Children's Research Hospital, Memphis, TN for testing. Veterinarians and herd owners are notified if animal specimens are test-positive for influenza. If swine ILI occurs, veterinarians obtain samples from the pigs; test-positives from the animals trigger nurses to obtain specimens (swabbing, acute and convalescent serology) from the swine workers. ProvLab cultures influenza virus from human specimens, freezes these cultures and human sera, and ships them to St. Jude where sera will be examined for antibodies to swine and human influenza virus strains or reassortants. Full length sequencing of all eight genes from the human and swine influenza isolates will be performed so that detailed comparisons can be performed between them. Discussion: The declaration of pandemic influenza in June 2009, caused by a novel H1N1 virus that includes avian, swine and human genes, highlights the importance of investigations of human/swine influenza transmission.
ACCESSION #
47323637

 

Related Articles

  • A Question of Proportion .  // Horizon Canada (English edition);Jan2001, pN.PAG 

    Details on the status of the Hutterite population in Canada. Estimates on the portion of land owned by the population; Share of the population in the total farm population of Alberta; Farm production rate of Manitoba's Hutterites.

  • A Hutterite Motif to Stitch. Morrissette, Nan Heldenbrand // Piecework;Jul/Aug2000, Vol. 8 Issue 4, p26 

    The article offers instructions for stitching a Hutterite handkerchief containing a flower motif.

  • A 'Managed Democracy' .  // Horizon Canada (English edition);Jan2001, pN.PAG 

    Focuses on the social organization of the Hutterite colony in Canada. Component of the colony executive; Approach in decision-making for the whole economy; Impetus to the influence of women on colony affairs.

  • Out of this World. Ryan, John // Horizon Canada (English edition);Jan2001, pN.PAG 

    Highlights the history of the Hutterite settlement in Canada. Impetus to the many detours made by the population; Measures taken by the population to ensure the preservation of their society; Type of clan groups composing the Hutterites.

  • Hutterite Sweetheart Handkerchiefs. McLeoid, Jim // Piecework;Jul/Aug2000, Vol. 8 Issue 4, p21 

    The article discusses the history of sweetheart handkerchiefs sewn by young women of the Hutterian Brethren, an agrarian society mainly based in northwestern North America. Young women would display their needlepoint skills by giving Hutterite sweetheart handkerchiefs to bachelors from whom they...

  • Antibody responses to intradermal or intramuscular MF59-adjuvanted influenza vaccines as evaluated in elderly institutionalized volunteers during a season of partial mismatching between vaccine and circulating A(H3N2) strains. Camilloni, Barbara; Basileo, Michela; Di Martino, Angela; Donatelli, Isabella; Maria, Anna // Immunity & Ageing;2014, Vol. 11, p2 

    Background The age-related weakening of the immune system makes elderly subjects less responsive to influenza vaccination. In the last years, two "enhanced vaccines" were licensed for individuals aged ⩾65 years, one being a subunit vaccine (Fluad®) containing the MF59 adjuvant...

  • ZANAMIVIR IN THE PREVENTION OF INFLUENZA AMONG HEALTHY ADULTS. Bower, Douglas J.; Slawson, James G. // Journal of Family Practice;Oct1999, Vol. 48 Issue 10, p748 

    The article presents information on a study which addressed the efficacy of zanamivir, a neuraminidase inhibitor, as a chemoprophylaxis agent for influenza. In the study, a total of 1107 healthy adults, mainly students and community volunteers aged 18 to 69 years, were recruited from the...

  • Low risk of recurrence of oculorespiratory syndrome following influenza revaccination. Skowronski, Danuta M.; Strauss, Barbara; Kendall, Perry; Duval, Bernard; Serres, GastonDe // CMAJ: Canadian Medical Association Journal;10/15/2002, Vol. 167 Issue 8, p853 

    Background During the 2000-2001 influenza vaccination season, a new adverse event associated with the influenza vaccine, called oculorespiratory syndrome (ORS), was identified in Canada. We examined the risk of recurrence of ORS for individuals affected in 2000-2001 who were revaccinated in the...

  • Occurrence, duration of live-attenuated influenza vaccine virus shedding. Block, Stan L. // Infectious Diseases in Children;Jun2008, Vol. 21 Issue 6, p28 

    The article discusses research on shedding and safety of live attenuated influenza vaccine in healthy subjects 6 to 60 months of age, presented by S. L. Block and K. S. Reisinger at the 2008 Annual Meeting of the Pediatric Academic Societies held from May 3-6 in Honolulu, Hawaii. According to...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics