Low bone mineral density is related to atherosclerosis in postmenopausal Moroccan women

Hmamouchi, Ihsane; Allali, Fadoua; Khazzani, Hamza; Bennani, Loubna; Mansouri, Leila E. L.; Ichchou, Linda; Cherkaoui, Mohammed; Abouqal, Redouane; Hajjaj-Hassouni, Najia
January 2009
BMC Public Health;2009, Vol. 9 Issue 1, p388
Academic Journal
Background: Some studies have implicated several possible metabolic linkages between osteoporosis and vascular calcification, including estrogen deficiency, vitamin D excess, vitamin K deficiency and lipid oxidation products. Nevertheless, it remains unclear whether osteoporosis and atherosclerosis are related to each other or are independent processes, both related to aging. The aim of this cross-sectional study was to evaluate the correlation between arterial thickening and bone status in a sample of apparently healthy Moroccan women. Methods: Seventy-two postmenopausal women were studied. All patients were without secondary causes that might affect bone density. Bone status was assessed by bone mineral density (BMD) in lumbar spine and all femoral sites. Arterial wall thickening was assessed by intima-media thickness (IMT) in carotid artery (CA) and femoral artery (FA). Prevalent plaques were categorized into four groups ranging from low echogenicity to high echogenicity. Results: The mean age was 59.2 ± 8.3 years. 84.7% had at least one plaque. By Spearman Rank correlation, CA IMT was negatively correlated to Femoral total BMD (r = -0.33), Femoral neck BMD (r = -0.23), Ward triangle BMD (r = -0.30) and Trochanter BMD (r = -0.28) while there was no association with lumbar BMD. In multiple regression analysis, CA IMT emerged as an independent factor significantly associated with all femoral sites BMD after adjusting of confounding factors. FA IMT failed to be significantly associated with both Femoral and Lumbar BMD. No significant differences between echogenic, predominantly echogenic, predominantly echolucent and echolucent plaques groups were found concerning lumbar BMD and all femoral sites BMD Conclusion: Our results demonstrate a negative correlation between bone mineral density (BMD) qnd carotid intima-media thickness (IMT) in postmenopausal women, independently of confounding factors. We suggest that bone status should be evaluated in patients with vascular disease to assess whether preventive or therapeutic intervention is necessarry.


Related Articles

  • postmenopause. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p620 

    A definition of the term "postmenopause" is presented. It refers to the period of woman's life in which ovulation and menstruation stop and menopause sets in.

  • Stążenie magnezu i cynku w surowicy u kobiet w wieku menopauzalnym w zależnoÅ›ci od statusu menopauzalnego i nasilenia objawów wypadowych. Grochans, Elżbieta; Karakiewicz, Beata; Brodowski, Jacek; Jurczak, Anna; Noceń, Iwona; Grzywacz, Anna; Augustyniuk, Katarzyna; Brodowska, Agnieszka // Menopausal Review / Przeglad Menopauzalny;2013, Vol. 12 Issue 4, p307 

    Background: Magnesium (Mg) and zinc (Zn) may affect the incidence and severity of climacteric symptoms in postmenopausal women. Objectives: The aim of this study was to assess serum Mg and Zn levels in postmenopausal women, depending on the severity of climacteric symptoms and the time interval...

  • Antimullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women's Health Across the Nation. Finkelstein, Joel S; Lee, Hang; Karlamangla, Arun; Neer, Robert M; Sluss, Patrick M; Burnett-Bowie, Sherri-Ann M; Darakananda, Karin; Donahoe, Patricia K; Harlow, Sioban D; Prizand, Sarah H; Joffe, Hadine; Kumar, Ajay; Martin, Deborah E; McConnell, Daniel; Merrilat, Steffenie; Morrison, Anthony; Pastore, Lisa M; Randolph, John F; Greendale, Gail A; Santoro, Nanette // Journal of Clinical Endocrinology & Metabolism;Jan 22, 2020, pN.PAG 

    Background: A test that helps predict the time to the final menstrual period (FMP) has been sought for many years.Objective: To assess the ability of antimullerian hormone (AMH) measurements to predictions the time to FMP.Design: Prospective longitudinal...

  • Midlife lipid changes found more related to the menopause than to ageing.  // Menopause International;Mar2010, Vol. 16 Issue 1, p2 

    The article focuses on a report from the Study of Women's Health Across the Nation (SWAN) released in the U.S. in 2010, revealing the impact of menopause on midlife lipid changes. It could not be confirmed whether menopause had an impact on a woman's risk of cardiovascular disease but the SWAN...

  • EXERCISE & MENOPAUSE.  // Body Bulletin;Nov2003, Vol. 4 Issue 11, p3 

    The article focuses on information related to menopause. Most women enter menopause in their early 50's when estrogen levels drop dramatically culminating in the cessation of ovulation and monthly periods. With the declining estrogen they face increased risk of heart disease, bone and muscle...

  • Menopause: What really happens.  // Consumer Reports on Health;Aug2001, Vol. 13 Issue 8, p7 

    Discusses the results of a study which examined women who were going through natural menopause. Symptoms of menopause; Increased frequency of flashes and night sweating in the postmenopausal phase; Indication that there was no significant increase in the frequency of other symptoms, including...

  • Síndrome metabólico en la menopausia, conceptos clave. Rojas J., Sara; Lopera V., Johan Sebastián; Cardona V., Jonathan; Vargas G., Natalia; Hormaza A., María Patricia // Revista Chilena de Obstetricia y Ginecología;2014, Vol. 79 Issue 2, p121 

    The transition experienced by women menopause is associated with the development of features of the metabolic syndrome (MS), among which include: increased core abdominal fat, abnormal lipid profile and insulin resistance. Therefore, the prevalence of MS is increased with menopause up to 60%....

  • Coronary Heart Disease in South-Asian Women. Gooneratne, M. D. P. // Journal of the South Asian Federation of Menopause Societies;Jul-Dec2013, Vol. 1 Issue 2, p84 

    With the demographic transition in the South-Asian region coronary heart disease in post menopausal women is a major challenge. Women with myocardial infarction often have atypical presentation and have a higher mortality. In South-Asia there is high prevalence of coronary heart disease among...

  • Tualang Honey Supplementation Reduces Blood Oxidative Stress Levels/Activities in Postmenopausal Women. Shafin, Nazlahshaniza; Othman, Zahiruddin; Zakaria, Rahimah; Nik Hussain, Nik Hazlina // ISRN Otolaryngology;2014, p1 

    This study aimed to investigate the ability of Tualang honey (TH), a phytoestrogen, to reduce blood oxidative stress levels/activities in postmenopausal women and compared the effects with the standard estrogen progestin therapy (EPT). A total of 78 healthy postmenopausal women were randomly...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics