Effect of Reactive Hyperemia on Carotid-Radial Pulse Wave Velocity in Hypertensive Participants and Direct Comparison With Flow-Mediated Dilation: A Pilot Study

Kamran, Haroon; Salciccioli, Louis; Eun Hee Ko; Qureshi, Ghazanfar; Kazmi, Haris; Kassotis, John; Lazar, Jason
January 2010
Angiology;Jan2010, Vol. 61 Issue 1, p100
Academic Journal
This pilot study assessed the effects of hyperemia on carotid-radial pulse wave velocity (PWV) in 39 normotensive (NT) and 23 hypertensive (HT) participants using applanation tonometry. Pulse wave velocity was measured at 1- and at 2-minute intervals. Baseline PWV was similar between the groups (P = .59). At 1 minute, PWV decreased (8.5 + 1.2 to 7.1 + 1.4 m/s, P < .001) in NT but not in HT (P = .83). Hyperemic PWV (ΔPWV) response differed between the groups (Δ16% vs + 1.0%, P < .001). On multivariate analysis, HT, not age or blood pressure was independently related to ΔPWV (R2 = .43, P < .01). Among patients with cardiovascular risk factors/disease, ΔPWV was inversely related to flow-mediated dilation (FMD; R2 = .43, P < .003). Conclusion: hyperemia decreases PWV1min in NT but not in HT. ΔPWV is inversely related to FMD. Blunted hyperemic PWV response may represent impaired vasodilatory reserve.


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