Diffusion tensor imaging detects age related white matter change over a 2 year follow-up which is associated with working memory decline

R A Charlton
January 2010
Journal of Neurology, Neurosurgery & Psychiatry;Jan2010, Vol. 81 Issue 1, p13
Academic Journal
BACKGROUND: Diffusion tensor imaging (DTI) is a sensitive method for detecting white matter damage, and in cross sectional studies DTI measures correlate with age related cognitive decline. However, there are few data on whether DTI can detect age related changes over short time periods and whether such change correlates with cognitive function. METHODS: In a community sample of 84 middle-aged and elderly adults, MRI and cognitive testing were performed at baseline and after 2 years. Changes in DTI white matter histograms, white matter hyperintensity (WMH) volume and brain volume were determined. Change over time in performance on tests of executive function, working memory and information processing speed were also assessed. RESULTS: Significant change in all MRI measures was detected. For cognition, change was detected for working memory and this correlated with change in DTI only. In a stepwise regression, with change in working memory as the dependent variable, a DTI histogram measure explained 10.8% of the variance in working memory. Change in WMH or brain volume did not contribute to the model. CONCLUSIONS: DTI is sensitive to age related change in white matter ultrastructure and appears useful for monitoring age related white matter change even over short time periods.


Related Articles

  • Experience-dependent plasticity in white matter microstructure: reasoning training alters structural connectivity. Mackey, Allyson P.; Whitaker, Kirstie J.; Bunge, Silvia A. // Frontiers in Neuroanatomy;Aug2012, Vol. 6, p1 

    Diffusion tensor imaging (DTI) techniques have made it possible to investigate white matter plasticity in humans. Changes in DTI measures, principally increases in fractional anisotropy (FA), have been observed following training programs as diverse as juggling, meditation, and working memory....

  • Diffusion tensor imaging of the superior cerebellar peduncle. Battal, Bilal; Hamcan, Salih; Akgun, Veysel // Child's Nervous System;Dec2013, Vol. 29 Issue 12, p2143 

    A letter to the editor is presented in response to the article related with diffusion tensor imaging.

  • Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography. Jeremy D. Schmahmann; Deepak N. Pandya; Ruopeng Wang; Guangping Dai; Helen E. D'Arceuil; Alex J. de Crespigny; Van J. Wedeen // Brain: A Journal of Neurology;Mar2007, Vol. 130 Issue 3, p630 

    Understanding the long association pathways that convey cortical connections is a critical step in exploring the anatomic substrates of cognition in health and disease. Diffusion tensor imaging (DTI) is able to demonstrate fibre tracts non-invasively, but present approaches have been hampered by...

  • Research on the Image Segmentation and Classification based on the Diffusion Tensor algorithm. Li Hua // International Journal of Digital Content Technology & its Applic;May2012, Vol. 6 Issue 8, p319 

    Diffusion tensor imaging which measures the diffusion characteristics of water molecules in the brain, is an important technique for inferring the structure of the white matter tracts. However, DTI data is often underexploited in current techniques for segmentation and classification of these...

  • Paediatric neuroimaging. Triulzi, Fabio // Neurological Sciences;Oct2008 Supplement 3, Vol. 29, p342 

    An increasing number of advanced magnetic resonance (MR) techniques are routinely performed in paediatric neuroradiology departments. The most diffuse technique, standard diffusion weighted imaging, is very fast and is becoming increasingly common in routine practice. The usefulness of...

  • Alzheimer’s disease and other dementing conditions. Tedeschi, Gioacchino; Cirillo, Mario; Tessitore, Alessandro; Cirillo, Sossio // Neurological Sciences;Oct2008 Supplement 3, Vol. 29, p301 

    Dementia is a common and growing problem, with 20% of those over 80 years of age suffering from this disorder. The prospect of more effective treatments has caused an increasing demand for a more accurate and earlier diagnosis of different dementia syndromes. Neuroimaging techniques may have an...

  • Basic concepts of advanced MRI techniques. Pagani, Elisabetta; Bizzi, Alberto; Di Salle, Francesco; De Stefano, Nicola; Filippi, Massimo // Neurological Sciences;Oct2008 Supplement 3, Vol. 29, p290 

    An overview is given of magnetic resonance (MR) techniques sensitized to diffusion, flow, magnetization transfer effect, and local field inhomogeneities induced by physiological changes, that can be viewed, in the clinical practice, as advanced because of their challenging implementation and...

  • Myelination in Bipolar Patients and the Effects of Mood Stabilizers on Brain Anatomy. Brambilla, Paolo; Bellani, Marcella; Ping-Hong Yeh; Soares, Jair C. // Current Pharmaceutical Design;8/1/2009, Vol. 15 Issue 22, p2632 

    In this review, we debate the evidence for abnormal white matter microstructure and myelination in bipolar disorder, as mainly detected by diffusion tensor imaging (DTI) studies. The effects of mood stabilizers on white matter are discussed, based on available findings from human and animal...

  • Fast GL( n)-Invariant Framework for Tensors Regularization. Gur, Yaniv; Pasternak, Ofer; Sochen, Nir // International Journal of Computer Vision;Dec2009, Vol. 85 Issue 3, p211 

    We propose a novel framework for regularization of symmetric positive-definite (SPD) tensors (e.g., diffusion tensors). This framework is based on a local differential geometric approach. The manifold of symmetric positive-definite (SPD) matrices, P n, is parameterized via the Iwasawa coordinate...


Read the Article


Sign out of this library

Other Topics