Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver

Takeichi, Takayuki; Uemoto, Shinji; Minamiguchi, Sachiko; Takeyoshi, Izumi; Inomata, Yukihiro; Tanaka, Koichi; Kobayashi, Eiji
December 2009
World Journal of Gastroenterology;12/7/2009, Vol. 15 Issue 45, p5712
Academic Journal
AIM: To investigate the effects of a novel Leukotriene B4 receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model. METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus). RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more significantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls. CONCLUSION: This study demonstrated that pretreatment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver ischemia-reperfusion injury.


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