Revisión crítica de la estimulación subtalámica en la enfermedad de Parkinson

Guridi, J.; Rodríguez-Oroz, M. C.; Clavero, P.; Manrique, M.
December 2009
Revista Neurocirugia;2009, Vol. 20 Issue 6, p521
Academic Journal
The authors critically review subthalamic nucleus (STN) stimulation for Parkinson's disease (PD) at long follow-up (3-5 years). Subthalamic stimulation induce a significant improvement during the “off” medication in the assessment motor score UPDRS (Unified Parkinson Disease Rating Scale) 3-5 years after surgery. Results show that the benefits obtained in tremor, rigidity, bradykinesia, dyskinesias induced by medication and levodopa reduction are significantly maintained during long term. The improvement in other clinical signs as gait and postural stability at long follow-up are not maintained comparing with the benefits obtained one year after surgery. A high percentage of patients show a cognitive disturbance during the follow-up period that may be correlated with the disease progression. The conclusion is that bilateral STN stimulation is an effective treatment for PD patients at long term but it should be considered earlier in the course of PD.


Related Articles

  • Absence of cognitive deficits following deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. Fraraccio, Maria; Ptito, Alain; Sadikot, Abbas; Panisset, Michel; Dagher, Alain // Archives of Clinical Neuropsychology;Jul2008, Vol. 23 Issue 4, p399 

    Abstract: Electrical stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson''s disease. While most patients who undergo this procedure do not appear to suffer behavioral side effects, a minority experience cognitive or emotional deficits, and...

  • Prevalence of primitive reflexes and the relationship with cognitive change in healthy adults. Boxtel, Martin P. J.; Bosma, Hans; Jolles, Jelle; Vreeling, Fred W. // Journal of Neurology;Jul2006, Vol. 253 Issue 7, p935 

    Objectives Primitive reflexes (PR) generally disappear early in life but may reappear later, in which case they are often associated with chronic neurological conditions, such as dementia or Parkinson's disease. Studies have shown that the presence of PRs may be indicative of both the severity...

  • NONMOTOR ASPECTS OF PARKINSON'S DISEASE. Britton, Thomas C. // Current Medical Literature: Neurology;2004, Vol. 20 Issue 3, p45 

    Examines the nonmotor aspects of Parkinson's disease. Cognition; Sensory systems; Autonomic system.

  • Deep-brain stimulation for Parkinson's disease. Deuschl, G.; Fogel, W.; Hahne, M.; Kupsch, A.; Müller, D.; Oechsner, M.; Sommer, U.; Ulm, G.; Vogt, T.; Volkmann, J. // Journal of Neurology;Dec2002 Supplement 3, Vol. 249, piii36 

    Deep brain simulation (DBS) is a powerful new therapeutic approach for patients with Parkinson's disease. However, patient selection is critical for a valuable therapeutic result. Dopa sensitivity of the target symptoms, severe disability and low neurosurgical risks are among the major criteria...

  • Pergolide effect on cognitive functions in early-mild Parkinson’s disease. Brusa, L.; Tiraboschi, P.; Koch, G.; Peppe, A.; Pierantozzi, M.; Ruggieri, S.; Stanzione, P. // Journal of Neural Transmission;Feb2005, Vol. 112 Issue 2, p231 

    In the present study, we evaluated the effect of pergolide, a mixed D1/D2 agonist, on cognitive function in mild Parkinson’s disease (PD). After a two-week wash-out phase, twenty patients with a Hoehn and Yahr score =2.5 entered a 16-week, cross-over study in which the order of...

  • Ballooned neurons in progressive supranuclear palsy are usually due to concurrent argyrophilic grain disease. Togo, Takashi; Dickson, Dennis W. // Acta Neuropathologica;Jul2002, Vol. 104 Issue 1, p53 

    Progressive supranuclear palsy (PSP) is a sporadic multisystem neurodegenerative disorder that is one of the major causes of parkinsonism, which shares common biochemical and genetic features with corticobasal degeneration (CBD). Ballooned neurons (BN) are one of the histopathologic hallmarks of...

  • The effect of cognitive status and visuospatial performance on affective theory of mind in Parkinson's disease. McKinlay, Audrey; Albicini, Michelle; Kavanagh, Phillip S. // Neuropsychiatric Disease & Treatment;2013, Vol. 9, p1071 

    It is now well accepted that theory of mind (ToM) functioning is impaired in Parkinson's disease (PD) patients. However, what remain unknown are the functions that underlie this impairment. It has been suggested that cognitive skills may be key in this area of functioning; however, many of the...

  • Is cognitive stability in Parkinson's disease a predictable phenomenon? A 5-year follow-up study. Battista, Maria; Rubino, Alfonso; Valente, Marcella; Giustini, Patrizia; Vanacore, Nicola; Meco, Giuseppe // Journal of Neural Transmission;Dec2015, Vol. 122 Issue 12, p1703 

    Cognitive disturbances are integral to the course of PD but the rate of cognitive decline remains largely unpredictable. The aim of this study was to determine the clinical features associated with 'cognitive stability'. Fifty-four patients (32 with normal cognition and 22 featuring MCI) were...

  • Cognitive and SPECT characteristics predict progression of Parkinson’s disease in newly diagnosed patients. Dujardin, Kathy; Defebvre, Luc; Duhamel, Alain; Lecouffe, Pascal; Rogelet, Pascal; Steinling, Marc; Destée, Alain // Journal of Neurology;Nov2004, Vol. 251 Issue 11, p1383 

    Objective To identify features in cognitive functioning and regional cerebral blood flow (rCBF) in newly diagnosed Parkinson's disease (PD) patients and to determine whether these factors are able to predict the progression of the disease in general and the development of cognitive decline in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics