TITLE

PPIs and Clopidogrel: Do We Have to Worry?

AUTHOR(S)
Kuritzky, Louis
PUB. DATE
December 2009
SOURCE
OB/GYN Clinical Alert;Dec2009, Vol. 26 Issue 8, p23
SOURCE TYPE
Periodical
DOC. TYPE
Article
ABSTRACT
The article reports on the pharmacological relation between proton pump inhibitor (PPI) and clopidogrel in the U.S. It mentions that the antiplatelet effect of clopidogrel depends on its conversion and activation through the 2C19 pathway of the P450 system where the blockade of this pathway happens when a person do not have sufficient active 2C19. In relation, it suggests that PPI need not be avoided when treating acute coronary syndromes with clopidogrel or prasugrel.
ACCESSION #
47139407

 

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