Integrated acoustic and magnetic separation in microfluidic channels

Adams, Jonathan D.; Thévoz, Patrick; Bruus, Henrik; Soh, H. Tom
December 2009
Applied Physics Letters;12/21/2009, Vol. 95 Issue 25, p254103
Academic Journal
With a growing number of cell-based biotechnological applications, there is a need for particle separation systems capable of multiparameter separations at high purity and throughput, beyond what is presently offered by traditional methods including fluorescence activated cell sorting and column-based magnetic separation. Toward this aim, we report on the integration of microfluidic acoustic and magnetic separation in a monolithic device for multiparameter particle separation. Using our device, we demonstrate high-purity separation of a multicomponent particle mixture at a throughput of up to 108 particles/hr.


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