TITLE

DNA-psoralen: Single-molecule experiments and first principles calculations

AUTHOR(S)
Rocha, M. S.; LĂșcio, A. D.; Alexandre, S. S.; Nunes, R. W.; Mesquita, O. N.
PUB. DATE
December 2009
SOURCE
Applied Physics Letters;12/21/2009, Vol. 95 Issue 25, p253703
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The authors measure the persistence and contour lengths of DNA-psoralen complexes, as a function of psoralen concentration, for intercalated and crosslinked complexes. In both cases, the persistence length monotonically increases until a certain critical concentration is reached, above which it abruptly decreases and remains approximately constant. The contour length of the complexes exhibits no such discontinuous behavior. By fitting the relative increase of the contour length to the neighbor exclusion model, we obtain the exclusion number and the intrinsic intercalating constant of the interaction. Ab initio calculations are employed in order to provide an atomistic picture of these experimental findings.
ACCESSION #
47132818

 

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