Synchrotron hard x-ray microprobe: Fluorescence imaging of single cells

Bohic, S.; Simionovici, A.; Snigirev, A.; Ortega, R.; Deves, G.; Heymann, D.; Schroer, C. G.
May 2001
Applied Physics Letters;5/28/2001, Vol. 78 Issue 22, p3544
Academic Journal
Imaging of trace elements in single cells was achieved by synchrotron-induced x-ray fluorescence (SXRF) in the hard x-ray range. Monochromatic and "pink" excitations at 14 keV were used with compound refractive lenses resulting in a 1x10 μm[sup 2] beam size. The experiment shows that SXRF is well suited for microanalysis of freeze-dried cells, and demonstrated high accuracy in quantitative imaging of trace element in cells treated with pharmacological doses of an iodine-labeled anticancer drug. © 2001 American Institute of Physics.


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