TITLE

Separation of peptides by HPLC using a surface-confined ionic liquid stationary phase

AUTHOR(S)
Chitta, K. R.; Van Meter, D. S.; Stalcup, A. M.
PUB. DATE
January 2010
SOURCE
Analytical & Bioanalytical Chemistry;Jan2010, Vol. 396 Issue 2, p775
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A butylimidazolium bromide surface-confined ionic liquid stationary phase was synthesized in-house. The synthesized phase was investigated for the separation of five peptides (Gly-Tyr, Val-Tyr-Val, leucine enkephalin, methionine enkephalin, and angiotensin-II). The peptides were successfully separated in less than 5 min. The effect of trifluoroacetic acid (TFA) on the separation of peptides was evaluated with results confirming that TFA was not acting as ion-pairing agent in separation of peptides on this phase.
ACCESSION #
47010441

 

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