TITLE

Prophylactic antiemetic therapy with droperidol in patients undergoing laparoscopic cholecystectomy

AUTHOR(S)
Fujii, Yoshitaka; Tanaka, Hiroyoshi; Toyooka, Hidenori
PUB. DATE
July 1999
SOURCE
Journal of Anesthesia;1999, Vol. 13 Issue 3, p140
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract Purpose. The incidence of postoperative nausea and vomiting (PONV) following laparoscopic cholecystectomy (LC) is relatively high when no prophylactic antiemetic is given. We have studied the efficacy of a commonly used and well-established antiemetic, droperidol, for the prevention of PONV in patients undergoing LC. Methods. In a randomized, double-blind, placebo-controlled study, 60 patients received placebo (saline) or droperidol 50 micro g.kg [sup -1] (maximum dose, 2.5 mg) intravenously immediately before the induction of anesthesia (n = 30 of each). A standard general anesthetic technique was employed throughout. Results. A complete response, defined as no PONV and no need for another rescue antiemetic medication during the first 24h after anesthesia, was 57% and 83% in patients who had received placebo and droperidol 50 pg.kg [sup -1], respectively (P < 0.05). No clinically serious adverse events were observed in any of the groups. Conclusion. Prophylactic antiemetic therapy with droperidol 50 micro g.kg [sup -1] (maximum dose, 2.5 mg) is highly effective for preventing PONV after LC.
ACCESSION #
4689767

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics