Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human estrogen receptor β locus

Tsukamoto, Kazuhiro; Inoue, Satoshi; Hosoi, Takayuki; Orimo, Hajime; Emi, M.
January 1998
Journal of Human Genetics;1998, Vol. 43 Issue 1, p73
Academic Journal
Abstract A gene for a second type of human estrogen receptor, the estrogen receptor beta (ESR beta), was recently identified. We isolated a polymorphic dinucleotide CA repeat marker from a genomic clone containing the human estrogen receptor beta gene. High heterozygosity (0.93) makes this polymorphism a useful marker in the genetic study of disorders affecting female endocrine systems; calcium metabolism; and breast, uterine, and ovarian cancers.


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