TITLE

Salivary coagulopathy and immunoglobulins in oral submucous fibrosis

AUTHOR(S)
Pinakapani, R.; Shambulingappa, P.; Shashikanth, M. C.
PUB. DATE
April 2009
SOURCE
Journal of Indian Academy of Oral Medicine & Radiology;Apr-Jun2009, Vol. 21 Issue 2, p62
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim: The etiopathogenesis of oral submucous fibrosis is still obscure. Immunological disorders have been associated with it and as the disease produces changes localized to the oral cavity, it is assumed that saliva may play an important role in the etiopathogenesis. The purpose of this study was to detect salivary coagulopathy, immunologic alterations and their comparison in oral submucous fibrosis patients and controls. Materials and Methods: Salivary coagulopathy procedures and quantitative estimations of serum immunoglobulins were carried out by serial radial immunodiffusion method in 60 oral submucous fibrosis patients and equal age- and sex-matched healthy controls. The obtained data was analyzed using Mann-Whitney and Chi-square tests. Results: The results indicated the presence of a precipitating factor in saliva responsible for salivary coagulopathy, dependent upon the severity of the disease and not on age, sex or duration of the disease. As compared to the controls, serum IgG and IgA, but not IgM levels were raised significantly among patients. IgG levels were increased in all the grades, while IgA levels were increased in Grade II and Grade III cases only. IgM levels in Grade II and Grade III cases showed no significant alterations, however, were reduced in Grade I cases. The serum immunoglobulin levels showed no correlation with the duration of the disease. Conclusion: Alteration in saliva and immunity do indicate an immunological basis in the etiopathogenesis of this complex clinical entity.
ACCESSION #
46816631

 

Related Articles

  • Determination of levels of salivary IgA subclasses in patients with minor recurrent aphthous ulcer. Saluja, Ramandeep; Kale, Alka; Hallikerimath, Seema // Journal of Oral & Maxillofacial Pathology (0973029X);Jan2012, Vol. 16 Issue 1, p49 

    Context: Recurrent Aphthous Ulcer (RAU) is an inflammatory disease characterized by recurrent, painful oral ulcers. It is of multifactorial etiology. Salivary immunoglobulins have important role in the protection of mucosal surfaces. Aim: The aim of this study was to determine salivary...

  • radioimmunodiffusion.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1965 

    A definition of the term "radioimmunodiffusion," which refers to a method of studying antigen-antibody interaction by use of radioisotope-labeled antigens or antibodies diffused through a gel, is presented.

  • The Effects of Active and Passive Participation in Musical Activity on the Immune System as Measured by Salivary Immunoglobulin A (SlgA). Kuhn, Dawn // Journal of Music Therapy;Spring2002, Vol. 39 Issue 1, p30 

    The purposes of this study were (a) to determine if musical activity would produce a significant change in the immune system as measured by Salivary Immunoglobulin A (SIgA), and (b) to determine if active participation in musical activity had a significantly different effect on the immune system...

  • immunodiffusion.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1161 

    A definition of the term "immunodiffusion," which refers to a test method wherein an antigen and antibody are placed in a gel to diffuse toward each other is presented.

  • Normal IgG and Impaired IgM Responses to Polysaccharide Vaccines. Molrine, Deborah C.; Siber, George R.; Samra, Yecheskel; Shevy, Drora Samra; MacDonald, Kristin; Cieri, Rocco; Ambrosino, Donna M. // Journal of Infectious Diseases;2/1/99, Vol. 179 Issue 2, p513 

    Studies immunoglobulin G (IgG) and immunoglobulin M (IgM) responses to polysaccharide vaccines in asplenic patients. Antibody responses to Haemophilus influenzae and meningococcal vaccines; Impairment in IgM responses to vaccines.

  • CROSS-REACTIVITY OF THE AXIAL FILAMENT ANTIGEN AS A CRITERION FOR CLASSIFICATION OF LEPTOSPIRA. Chang, Annabella; Faine, S.; Williams, W.T. // Australian Journal of Experimental Biology & Medical Science;Jun1974, Vol. 52 Issue 3, p549 

    Establishes the relationship among 36 strains of leptospires, classified in the monospecific genus Leptospira, belonging to 15 serogroups using the cross-reactivity of the axial filament antigen in the immunodiffusion reaction as a criterion. Strategy used in the analysis of the pattern of...

  • Characterization of Pantoea agglomerans lipopolysaccharides. Varbanets, L.; Brovarskaya, O.; Bulygina, T.; Garkavaya, E.; Zhitkevich, N. // Microbiology (00262617);Nov2014, Vol. 83 Issue 6, p754 

    Lipopolysaccharides (LPS) from seven Pantoea agglomerans strains isolated from various plants were purified and chemically identified. LPS of the studied P. agglomerans strains were heterogeneous in monosaccharide composition. Thus, the LPS of P. agglomerans 8606 differed considerably from the...

  • immunodiffusion.  // Taber's Cyclopedic Medical Dictionary;2005, p1075 

    A definition of the medical term "immunodiffusion" is presented. Immunodiffusion refers to a test method in which an antigen and antibody are placed in a gel, where they diffuse toward each other. When they meet, a precipitate is formed. The definition is from the "Taber's Cyclopedic Medical...

  • electroimmunodiffusion.  // Taber's Cyclopedic Medical Dictionary;2005, p678 

    A definition of the medical term "electroimmunodiffusion" is presented. Electroimmunodiffusion refers to a laboratory method of identifying antigens in the blood by creating an artificial antigen-antibody reaction. The definition is from the "Taber's Cyclopedic Medical Dictionary," published by...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics