Primary hyperoxaluria 1: catch up growth and normalization of oxaluria 6 years after hepatorenal transplantation in a prepubertal boy

Walden, U.; Böswald, M.; Dörr, H. G.; Ruder, H.
September 1999
European Journal of Pediatrics;1999, Vol. 158 Issue 9, p727
Academic Journal
Abstract We present data on urinary oxalate (U[sub ox]), renal function, growth and bone age in a 10-year-old male with primary hyperoxaluria type 1. The patient had undergone combined liver-kidney transplantation at the age of 4.5 years. U[sub ox] increased up to 10[sup 4] micro mol/24 h after transplantation and declined to normal values thereafter. Excessive U[sub ox] concentrations after surgery might have been due to a bone pool of unsoluble oxalate and declined spontaneously. Creatinine clearance remained stable during observation period. The boy showed significant catch up growth. Height standard deviation score for chronological age improved from -2.4 before transplantation to -0.3 after 6 years. Radiological bone density improved at the same time.


Related Articles

  • Intra-operative continuous renal replacement therapy during combined liver–kidney transplantation in two patients with primary hyperoxaluria type 1. Franssen, Casper F. M.; Kema, Ido P.; Eleveld, Douglas J.; Porte, Robert J.; Van der Heide, Jaap J. Homan // NDT Plus;Apr2011, Vol. 4 Issue 2, p113 

    Liver–kidney transplantation in patients with primary hyperoxaluria type 1 (PH1) and a high systemic oxalate load is often complicated by oxalate deposition in the renal allograft and loss of renal function. Intensive pre- and post-operative haemodialysis (HD) cannot completely prevent...

  • Pulsatile Perfusion of Older Kidneys Is Medically Desirable.  // Kidney;Sep/Oct98, Vol. 7 Issue 5, p217 

    Discusses the abstract of a study entitled 'National impact of pulsatile perfusion on cadaveric kidney transplantation,' by J.F. Burdick, J.D. Rosendale, M.A. McBride and others, published in the 1997 issue of 'Transplantation.'

  • Frequent Early Biopsies Detect Subclinical Rejection, Improve Graft Survival.  // Kidney;Jul/Aug99, Vol. 8 Issue 4, p168 

    Investigates whether treating subclinical rejection with corticosteroids was associated with improved renal outcomes in renal transplant recipients (RTR). Advantages offered by early biopsies and treatment of subclinical rejection with corticosteroids in terms of leading to better histologic...

  • Re: Ureteral Length in Live Donor Kidney Transplantation: Does Size Matter? L. S., Ooms; I. K., Slagt; F. J., Dor; H. J., Kimenai; K. T., Tran; J. N., IJzermans; T., Terkivatan; M. G., Betjes // Journal of Urological Surgery;Dec2015, Vol. 2 Issue 4, p207 

    The article discusses the impact of ureteral length on urological complications for living donor kidney recipients.

  • Woman, 26, with Kidney Stones. Zuber, Kim // Clinician Reviews;Mar2011, Vol. 21 Issue 3, p8 

    The article discusses the case of a 26-year-old woman with kidney stones, a condition leading to uremia and acute kidney failure. It discusses primary hyperoxaluria (PHO) type I, a very rare recessive hereditary disease in which patients present with kidney stones at an early age or in full...

  • Oxalobacter formigenes: a potential tool for the treatment of primary hyperoxaluria type 1. Hoppe, B; Beck, B; Gatter, N; von Unruh, G; Tischer, A; Hesse, A; Laube, N; Kaul, P; Sidhu, H // Kidney International;Oct2006, Vol. 70 Issue 7, p1305 

    Primary hyperoxaluria is characterized by severe urolithiasis, nephrocalcinosis, and early renal failure. As treatment options are scarce, we aimed for a new therapeutic tool using colonic degradation of endogenous oxalate by Oxalobactor formigenes. Oxalobacter was orally administered for 4...

  • Role of Anti-Interleukin-2 Receptor Antibodies in Kidney Transplantation. Cibrik, D.M.; Kaplan, B.; Meier-Kriesche, H-U. // BioDrugs;2001, Vol. 15 Issue 10, p655 

    From the early 1960s, the mainstay of immunosuppression for kidney transplantation has been corticosteroids. Since then, many new drugs have been developed to maintain the renal allograft. Current maintenance immunosuppression commonly consists of corticosteroids, antiproliferative agents and...

  • Color Doppler energy – a new technique to study tissue perfusion in renal transplants. Hoyer, P. F.; Schmid, Raoul; Wünsch, Lutz; Vester, Udo // Pediatric Nephrology;1999, Vol. 13 Issue 7, p559 

    Information on renal tissue perfusion after transplantation remains important for renal allograft monitoring. Findings obtained by conventional Doppler sonography are limited to vascular resistance (RI). The new technique color Doppler energy (CDE) is Doppler angle independent, omits flow...

  • Desmospressin Does Not Change Long-Term Renal Graft Function.  // Kidney;Jul/Aug99, Vol. 8 Issue 4, p164 

    Studies the effects of desmopressin administered to brain-dead kidney donors (BDKD) on early and long-term graft function in kidney recipients. Safety of administering desmopressin to BDKD to limit harmful consequences of diabetes insipidus with no subsequent effect on long-term graft function.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics