TITLE

The effect of Propofol Fentanyl and Propofol Butorphanol on the increase in intraocular pressure due to succinylcholine and intubation

AUTHOR(S)
Singh, Vinita; Kaushal, Dinesh; Singh, Sarita; Bhatia, V. K.; Singh, G. P.
PUB. DATE
June 2009
SOURCE
Internet Journal of Anesthesiology;2009, Vol. 21 Issue 1, p24
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The increase in intraocular pressure (IOP) associated with succinylcholine (Sch) has made its use in patients with open globe injuries controversial. Studies that have examined techniques to prevent the increase in IOP due to Sch have shown a larger increase in IOP from the stimulus of laryngoscopy and endotracheal intubation. We investigated whether butorphanol in combination with propofol could attenuate this increase in IOP during induction of anaesthesia, laryngoscopy and intubation. Sixty patients of either sex, aged 20-50 years undergoing elective non-ophthalmic surgery under general anesthesia, were randomized blindly to receive either placebo, fentanyl 2μg/kg or butorphanol 1 mg, 15 min before induction of anaesthesia with propofol. Endotracheal intubation was facilitted with succinylcholine 2mg/kg. IOP and hemodynamic variables (HR, SAP and O2 saturation) measured before induction (baseline), after propofol, after Sch, and at 1 min, 3 min, 5 min and 10 min after intubation. Butorphanol in combination with propofol effectively obtunded the hemodynamic response as well as increase in IOP after Sch and intubation, without any increase in adverse events. Butorphanol 1 mg was found to be equipotent to 2μg/kg fentanyl in this respect.
ACCESSION #
45666038

 

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