2009 - Review: PPI use in pregnancy was not associated with increased congenital malformations, spontaneous abortion, or preterm delivery

Bharucha, Adil E.; Koren, G.
November 2009
ACP Journal Club;11/17/2009, Vol. 151 Issue 5, p12
Academic Journal
The article presents a study which examines the safety of proton-pump inhibitors (PPIs) taken during early pregnancy and its effects on the fetus. PPIs are used to treat reflux and omeprazole increases embryonic and fetal mortality in animals. However, no evidence was found to show that the use of PPIs during the first trimester of pregnancy results in increased risk for congenital malformations, spontaneous abortion, or preterm delivery.


Related Articles

  • PPI use during early pregnancy appears safe.  // Reactions Weekly;12/11/2010, Issue 1331, p2 

    The article discusses research being done on the application of proton-pump inhibitors (PPIs) in early pregnancy and its association with the risk of birth defects. It references a study by Björn Pasternak and colleagues in the November 2010 issue of the "New England Journal of Medicine." For...

  • omeprazole.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1628 

    A definition of the term "omeprazole" which refers to an inhibitor of the gastric acid formation is presented.

  • DIFFERENCES IN PPIs. Schwartz, Steven // Clinical Advisor;Feb2010, Vol. 13 Issue 2, p76 

    The article provides an answer to a question on the cost and effectiveness of omeprazole and proton pump inhibitors (PPIs).

  • Tissue Sampling Technique Affects Accuracy of Karyotype from Missed Abortions. Lathi, Ruth B.; Milki, Amin B. // Journal of Assisted Reproduction & Genetics;Nov2002, Vol. 19 Issue 11, p536 

    Determines if careful specimen selection and washing of tissue from first trimester missed abortion products of conception specimens increases the sensitivity of routine cytogenetics in detecting aneuploidy. Percentage of 46XX results decreased in the test group when compared to historical and...

  • Long-term PPI therapy safe.  // Reactions Weekly;May2015, Vol. 1553 Issue 1, p7 

    The article focuses on a study which shows that long-term treatment with the proton pump inhibitors omeprazole and esomeprazole is not linked with any safety concern.

  • Proton-Pump Inhibitors and Birth Defects � Some Reassurance, but More Needed. Mitchell, Allen A. // New England Journal of Medicine;11/25/2010, Vol. 363 Issue 22, p2161 

    The author reflects on the effect of the use of proton-pump inhibitors (PPIs) during pregnancy on the occurrence of birth defects. It presents the study conducted in Denmark, which showed that the use of PPIs like omeprazole, lansoprazole and esomeprazole has no major effect on the possibility...

  • Valproic acid use in pregnancy ups risk of malformations.  // Reactions Weekly;7/10/2010, Issue 1309, p2 

    The article discusses a study which found that valproic acid monotherapy during the first trimester of pregnancy could increase the risk of congenital malformations in the offspring of the pregnant women.

  • Drug points. Bong, J L; Lucke, T W; Douglas, W S // BMJ: British Medical Journal (International Edition);01/29/2000, Vol. 320 Issue 7230, p283 

    Offers a look on a case of lichenoid eruption in reaction to proton pump inhibitors. Clinical manifestations of the skin disease; Mechanism of action of the inhibitor; Adverse effects of omeprazole.

  • Drug interaction studies with esomeprazole, the (S)-isomer of omeprazole. Andersson, T.; Hassan-Alin, M.; Hasselgren, G.; Röhss, K.; Röhss, K // Clinical Pharmacokinetics;2001, Vol. 40 Issue 7, p523 

    Esomeprazole, the (S)-isomer of omeprazole, is the first proton pump inhibitor (PPI) developed as a single isomer for the treatment of patients with acid related diseases. Because of the extensive use of PPIs, the documentation of the potential for drug interactions with esomeprazole is of great...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics